Background: Little is known about CD4 cell count changes in patients with high CD4 cell counts who interrupt antiretroviral therapy, especially in those with a nadir of 250350 x 10(6) cells/I. Methods: Data derived from 139 patients from seven prospective cohorts who had > 12 months highly active antiretroviral therapy (HAART), CD4 cell count nadir of > 250 x 10(6) cells/I and at pre-interruption of > 500 x 106 cells/I. Endpoint was time to CD4 cell count < 350 x 10(6) cells/I or reinitiation of treatment. Results: At interruption, the median CD4 cell count was 800 x 106 cells/I, median viral load was 1.7 log(10) copies/ml. At the time of analysis, 63 (45.3%) had resumed therapy or experienced < 350 x 10(6) cells/I CD4 cells over a median interruption of 75 weeks. Of these, 33 (52.4%) experienced a decline to < 350 x 10(6) cells/I and 30 (47.6%) restarted therapy before their CD4 cell count had fallen below this level. In 43 patients with CD4 cell nadir of 251-350 x 10(6) cells/I, median time to therapy resumption or CD4 cell count < 350 x 10(6) cells/I was 61 weeks. Higher CD4 cell count nadir, longer duration of viral load suppression on therapy, and higher viral load level at interruption were independently associated with longer time to restart therapy. The risk of clinical events was 5 per 1000 person-years of follow-up. Conclusions: Patients who started therapy with CD4 cell count of 250-350 x 10(6) cells/I and who later interrupted therapy appear able to remain off therapy with a CD4 cell count > 350 x 10(6) cells/I for a substantial period of time.

CD4 cell-monitored treatment interruption in patients with a CD4 cell count > 500 x 10(6) cells/I / Mussini, Cristina; Bedini, Andrea; V., Borghi; Guaraldi, Giovanni; Esposito, Roberto; E., Barchi; R., Emilia; A., Cozzi Lepri; A. N., Phillips; P., Ortolani; Cossarizza, Andrea; G., Bratt; L. E., Eriksson; L., Sighinolfi; A. D., Monforte; A., De Luca; S., Di Giambenedetto; A., Antinori. - In: AIDS. - ISSN 0269-9370. - STAMPA. - 19:3(2005), pp. 287-294.

CD4 cell-monitored treatment interruption in patients with a CD4 cell count > 500 x 10(6) cells/I

MUSSINI, Cristina;BEDINI, Andrea;GUARALDI, Giovanni;ESPOSITO, Roberto;COSSARIZZA, Andrea;
2005

Abstract

Background: Little is known about CD4 cell count changes in patients with high CD4 cell counts who interrupt antiretroviral therapy, especially in those with a nadir of 250350 x 10(6) cells/I. Methods: Data derived from 139 patients from seven prospective cohorts who had > 12 months highly active antiretroviral therapy (HAART), CD4 cell count nadir of > 250 x 10(6) cells/I and at pre-interruption of > 500 x 106 cells/I. Endpoint was time to CD4 cell count < 350 x 10(6) cells/I or reinitiation of treatment. Results: At interruption, the median CD4 cell count was 800 x 106 cells/I, median viral load was 1.7 log(10) copies/ml. At the time of analysis, 63 (45.3%) had resumed therapy or experienced < 350 x 10(6) cells/I CD4 cells over a median interruption of 75 weeks. Of these, 33 (52.4%) experienced a decline to < 350 x 10(6) cells/I and 30 (47.6%) restarted therapy before their CD4 cell count had fallen below this level. In 43 patients with CD4 cell nadir of 251-350 x 10(6) cells/I, median time to therapy resumption or CD4 cell count < 350 x 10(6) cells/I was 61 weeks. Higher CD4 cell count nadir, longer duration of viral load suppression on therapy, and higher viral load level at interruption were independently associated with longer time to restart therapy. The risk of clinical events was 5 per 1000 person-years of follow-up. Conclusions: Patients who started therapy with CD4 cell count of 250-350 x 10(6) cells/I and who later interrupted therapy appear able to remain off therapy with a CD4 cell count > 350 x 10(6) cells/I for a substantial period of time.
2005
19
3
287
294
CD4 cell-monitored treatment interruption in patients with a CD4 cell count > 500 x 10(6) cells/I / Mussini, Cristina; Bedini, Andrea; V., Borghi; Guaraldi, Giovanni; Esposito, Roberto; E., Barchi; R., Emilia; A., Cozzi Lepri; A. N., Phillips; P., Ortolani; Cossarizza, Andrea; G., Bratt; L. E., Eriksson; L., Sighinolfi; A. D., Monforte; A., De Luca; S., Di Giambenedetto; A., Antinori. - In: AIDS. - ISSN 0269-9370. - STAMPA. - 19:3(2005), pp. 287-294.
Mussini, Cristina; Bedini, Andrea; V., Borghi; Guaraldi, Giovanni; Esposito, Roberto; E., Barchi; R., Emilia; A., Cozzi Lepri; A. N., Phillips; P., Or...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/306497
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