Herpes simplex virus 1 meningo-encephalitis was ascertained in a 63-year-old immunocompetent man. To determine the duration of the persistence of herpesvirus DNA in the central nervous system, the cerebrospinal fluid was periodically monitored by polymerase chain reaction for 53 days. In addition to HSV-1, Epstein - Barr virus DNA was detected in the cerebrospinal fluid 9 days after disease onset. The possible meaning of the Epstein-Barr virus DNA finding is discussed.
Epstein-Barr virus DNA in cerebrospinal fluid from an immunocompetent man with herpes simplex virus encephalitis / Portolani, Marinella; Sabbatini, Anna Maria Teresa; M., Meacci; P., Pietrosemoli; Cermelli, Claudio; P., Lunghi; F., Golinelli; R., Stacca. - In: JOURNAL OF NEUROVIROLOGY. - ISSN 1355-0284. - 4:(1998), pp. 461-464.