In vivo effects of acute stress induced by corticosterone 21-acetate in male Gallus domesticus thymus are studied and the steroid actions are evaluated in terms of cell proliferation, apoptosis and cytokine response in 10- and 21-day-old chickens. Steroid treatment induced thymocyte apoptosis and cell death decreased in the cortical-medullar direction and was more evident in younger animals. 24 h after treatment, the observed effect was reversed. The mitotic activity and thymic cells containing cytokine-like molecules were also affected. Indeed, the acute stress stimulated cytokine immunoreactivity to anti-IL-1alpha, IL-6 and TNF-alpha. antibodies both in epithelial cells and interdigitating cells located in medullar and cortical-medullar regions. The increased cytokine expression observed after 12 h was maintained after 24 h. The comparison between 10-and 21-day-old chickens showed a lower number of cells containing cytokine-like molecules in younger specimens. The present findings suggest that cytokines activated by acute stress in vivo could contribute to restoring immunological homeostasis and influence thymic glucocorticoid-mediated functions.
|Data di pubblicazione:||2004|
|Titolo:||Corticosterone 21-acetate in vivo induces acute stress in chicken thymus: cell proliferation, apoptosis and cytokine responses|
|Autore/i:||Franchini, Antonella; Marchesini, Erika; Ottaviani, Enzo|
|Codice identificativo ISI:||WOS:000222112300004|
|Codice identificativo Scopus:||2-s2.0-3042740792|
|Codice identificativo Pubmed:||15168329|
|Citazione:||Corticosterone 21-acetate in vivo induces acute stress in chicken thymus: cell proliferation, apoptosis and cytokine responses / Franchini, Antonella; Marchesini, Erika; Ottaviani, Enzo. - In: HISTOLOGY AND HISTOPATHOLOGY. - ISSN 0213-3911. - STAMPA. - 19(2004), pp. 693-699.|
|Tipologia||Articolo su rivista|
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