Experimental data support a role for GH and IGF-I in the reproductive process in humans, but the effect of chronic GH excess on gonadal and reproductive function in men has been never investigated. To understand the effects of short-term GH and IGF-I suppression on the gonadal axis and seminal fluid characteristics in men with acromegaly, we evaluated 35 patients (age 27-59 yr) with active disease and 35 age-matched healthy controls. Gonadal hormones and seminal fluid analysis were evaluated before and 6 months after surgery or lanreotide (LAN) (60 mg/month). At study entry, FSH, testosterone (T), and dihydrotestosterone (DHT) (P < 0.0001) levels, seminal volume, sperm count, total motility and forward progression, normal morphology, and vitality were significantly lower in patients with acromegaly than in controls. After 6 months, 22 patients achieved disease control after surgery (n = 11) or LAN (n = 11), whereas 13 had uncontrolled disease. Serum T and DHT levels and sperm number significantly increased in all groups. FSH and LH levels and total motility increased only in patients achieving disease control. Posttreatment IGF-I levels significantly correlated with total motility (r = -0.45; P = 0.006). In conclusion, short-term GH and IGF-I suppression after surgery or LAN significantly increased T and DHT levels and improved sperm number and motility in acromegalic men.

Short-term suppression of GH and IGF-I levels improves gonadal function and sperm parameters in men with acromegaly / Anna Maria, Colao; Michele De, Rosa; Rosario, Pivonello; Balestrieri, Antonio; Paolo, Cappabianca; Antonella Di, Sarno; Rochira, Vincenzo; Carani, Cesare; Gaetano, Lombardi. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - ELETTRONICO. - 87:(2002), pp. 4193-4197. [10.1210/jc.2002-020453]

Short-term suppression of GH and IGF-I levels improves gonadal function and sperm parameters in men with acromegaly

BALESTRIERI, Antonio;ROCHIRA, Vincenzo;CARANI, Cesare;
2002

Abstract

Experimental data support a role for GH and IGF-I in the reproductive process in humans, but the effect of chronic GH excess on gonadal and reproductive function in men has been never investigated. To understand the effects of short-term GH and IGF-I suppression on the gonadal axis and seminal fluid characteristics in men with acromegaly, we evaluated 35 patients (age 27-59 yr) with active disease and 35 age-matched healthy controls. Gonadal hormones and seminal fluid analysis were evaluated before and 6 months after surgery or lanreotide (LAN) (60 mg/month). At study entry, FSH, testosterone (T), and dihydrotestosterone (DHT) (P < 0.0001) levels, seminal volume, sperm count, total motility and forward progression, normal morphology, and vitality were significantly lower in patients with acromegaly than in controls. After 6 months, 22 patients achieved disease control after surgery (n = 11) or LAN (n = 11), whereas 13 had uncontrolled disease. Serum T and DHT levels and sperm number significantly increased in all groups. FSH and LH levels and total motility increased only in patients achieving disease control. Posttreatment IGF-I levels significantly correlated with total motility (r = -0.45; P = 0.006). In conclusion, short-term GH and IGF-I suppression after surgery or LAN significantly increased T and DHT levels and improved sperm number and motility in acromegalic men.
87
4193
4197
Short-term suppression of GH and IGF-I levels improves gonadal function and sperm parameters in men with acromegaly / Anna Maria, Colao; Michele De, Rosa; Rosario, Pivonello; Balestrieri, Antonio; Paolo, Cappabianca; Antonella Di, Sarno; Rochira, Vincenzo; Carani, Cesare; Gaetano, Lombardi. - In: THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM. - ISSN 0021-972X. - ELETTRONICO. - 87:(2002), pp. 4193-4197. [10.1210/jc.2002-020453]
Anna Maria, Colao; Michele De, Rosa; Rosario, Pivonello; Balestrieri, Antonio; Paolo, Cappabianca; Antonella Di, Sarno; Rochira, Vincenzo; Carani, Cesare; Gaetano, Lombardi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/306415
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