Experimental data support a role for GH and IGF-I in the reproductive process in humans, but the effect of chronic GH excess on gonadal and reproductive function in men has been never investigated. To understand the effects of short-term GH and IGF-I suppression on the gonadal axis and seminal fluid characteristics in men with acromegaly, we evaluated 35 patients (age 27-59 yr) with active disease and 35 age-matched healthy controls. Gonadal hormones and seminal fluid analysis were evaluated before and 6 months after surgery or lanreotide (LAN) (60 mg/month). At study entry, FSH, testosterone (T), and dihydrotestosterone (DHT) (P < 0.0001) levels, seminal volume, sperm count, total motility and forward progression, normal morphology, and vitality were significantly lower in patients with acromegaly than in controls. After 6 months, 22 patients achieved disease control after surgery (n = 11) or LAN (n = 11), whereas 13 had uncontrolled disease. Serum T and DHT levels and sperm number significantly increased in all groups. FSH and LH levels and total motility increased only in patients achieving disease control. Posttreatment IGF-I levels significantly correlated with total motility (r = -0.45; P = 0.006). In conclusion, short-term GH and IGF-I suppression after surgery or LAN significantly increased T and DHT levels and improved sperm number and motility in acromegalic men.
|Anno di pubblicazione:||2002|
|Titolo:||Short-term suppression of GH and IGF-I levels improves gonadal function and sperm parameters in men with acromegaly|
|Autore/i:||Anna Maria Colao; Michele De Rosa; Rosario Pivonello; A. Balestrieri; Paolo Cappabianca; Antonella Di Sarno; V. Rochira; C. Carani; Gaetano Lombardi|
|Digital Object Identifier (DOI):||10.1210/jc.2002-020453|
|Codice identificativo ISI:||WOS:000178201200030|
|Codice identificativo Scopus:||2-s2.0-0036736808|
|Codice identificativo Pubmed:||12213870|
|Tipologia||Articolo su rivista|
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