High-performance liquid chromatographic methods have been developed for stereoselective separations of terfenadine and its active metabolite fexofenadine.Satisfactory enantioseparations of racemic terfenadine were achieved on a Chiralcel column by normal phase elution. Analysis of racemic fexofenadine, as such, took a very long time and achieved poor enantioselectivity on this column; nevertheless, the analyte when derivatised with diazomethane was well resolved.Racemic fexofenadine was also derivatised using a chiral agent: R-(+)-1-phenylethylisocyanate and subjected to achiral LC on a reversed-phase analytical column. Complete enantioseparations were achieved in short analysis times; excess reagent eluted before the diastereoisomeric pair and did not interfere.

Enantioselective analyses of antihistaminic drugs by high performance liquid chromatography / Rustichelli, Cecilia; Gamberini, Maria Cristina; V., Ferioli; Gamberini, Gianfranco. - In: CHROMATOGRAPHIA. - ISSN 0009-5893. - ELETTRONICO. - 60:(2004), pp. 99-103.

Enantioselective analyses of antihistaminic drugs by high performance liquid chromatography

RUSTICHELLI, Cecilia;GAMBERINI, Maria Cristina;GAMBERINI, Gianfranco
2004

Abstract

High-performance liquid chromatographic methods have been developed for stereoselective separations of terfenadine and its active metabolite fexofenadine.Satisfactory enantioseparations of racemic terfenadine were achieved on a Chiralcel column by normal phase elution. Analysis of racemic fexofenadine, as such, took a very long time and achieved poor enantioselectivity on this column; nevertheless, the analyte when derivatised with diazomethane was well resolved.Racemic fexofenadine was also derivatised using a chiral agent: R-(+)-1-phenylethylisocyanate and subjected to achiral LC on a reversed-phase analytical column. Complete enantioseparations were achieved in short analysis times; excess reagent eluted before the diastereoisomeric pair and did not interfere.
60
99
103
Enantioselective analyses of antihistaminic drugs by high performance liquid chromatography / Rustichelli, Cecilia; Gamberini, Maria Cristina; V., Ferioli; Gamberini, Gianfranco. - In: CHROMATOGRAPHIA. - ISSN 0009-5893. - ELETTRONICO. - 60:(2004), pp. 99-103.
Rustichelli, Cecilia; Gamberini, Maria Cristina; V., Ferioli; Gamberini, Gianfranco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/306405
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