Prevalence of berylliosis, a lung disorder driven by the activation of beryllium-specific T cells, is associated with a major histocompatibility complex (MHC) class II marker (HLA-DPB1Glu69) and with the type of industrial exposure. We evaluated the interaction between marker and exposure in a beryllium-exposed population in which the prevalence of berylliosis was associated with machining beryllium. The presence of the marker was associated with higher prevalence (HLA-DPB1Glu69-positive machinists 25%; HLA-DPB1Glu69-negative machinists 3.2%, P = 0.05) and predicted berylliosis independent of machining history (odds ratios 11.8 and 10.1). The study shows that in berylliosis the carrier status of a genetic susceptibility factor adds to the effect of process-related risk factors.
Interaction of genetic and exposure factors in the prevalence of berylliosis / Richeldi, Luca; K., Kreiss; Mm, Mroz; Bg, Zhen; P., Tartoni; C., Saltini. - In: AMERICAN JOURNAL OF INDUSTRIAL MEDICINE. - ISSN 0271-3586. - STAMPA. - 32:(1997), pp. 337-340.