Objective: To test whether transdermal holmone therapy can be safely administered to postmenopausal women with chronic viral hepatitis B and/or C. Design: Eighty-one postmenopausal women with chronic viral hepatitis B and/or C and with severe vasomotor symptoms were treated for 5 years with transdermal estradiol (50 mu g/day) continuously and with transdennal norethisterone (250 mu g/day) for 14 days of every 28-day cycle. Another 95 women with viral chronic hepatitis but without climacteric symptoms were used as controls. Liver enzymes (glutamic-oxalacetic transaminase, glutamic-pyruvic transarninase, gamma-glutamine-transferase, and alkaline phosphatase) were measured every year. Results: At baseline, liver enzymes were similar in the two groups, with the exception of gamma-GT, which was slightly higher in untreated women (P < 0.01). Liver enzymes did not significantly vary with time in hormone-treated and untreated women. No significant difference was observed between the two groups. Conclusions: Transdermal estradiol and norethisterone can be safely administered for a prolonged period to postmenopausal women with chronic viral B and/or C hepatitis.
Neutral effect of prolonged transdermal hormone therapy on liver function of postmenopausal women with chronic active hepatitis / Rinaldi, M; Cagnacci, Angelo; Pansini, Fe; de Aloysio, D; Sgarabotto, Mp; Bacchi Modena, A.. - In: MENOPAUSE. - ISSN 1072-3714. - STAMPA. - 12(2005), pp. 619-622.
Data di pubblicazione: | 2005 |
Titolo: | Neutral effect of prolonged transdermal hormone therapy on liver function of postmenopausal women with chronic active hepatitis |
Autore/i: | Rinaldi, M; Cagnacci, Angelo; Pansini, Fe; de Aloysio, D; Sgarabotto, Mp; Bacchi Modena, A. |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 12 |
Pagina iniziale: | 619 |
Pagina finale: | 622 |
Codice identificativo ISI: | WOS:000235114300019 |
Codice identificativo Scopus: | 2-s2.0-25444510342 |
Codice identificativo Pubmed: | 16145317 |
Citazione: | Neutral effect of prolonged transdermal hormone therapy on liver function of postmenopausal women with chronic active hepatitis / Rinaldi, M; Cagnacci, Angelo; Pansini, Fe; de Aloysio, D; Sgarabotto, Mp; Bacchi Modena, A.. - In: MENOPAUSE. - ISSN 1072-3714. - STAMPA. - 12(2005), pp. 619-622. |
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