The work aims to provide a histological investigation of Fisiograft(R) a PLA/PGA copolymer, used as filler for bone defects in humans. The study was performed on biopsies of sinus lifts where Bio-Oss(R) and Fisiograft(R) gel were applied as graft material. Bone regeneration was satisfactory in all sinus lifts, even when Fisiograft(R) was applied alone. Due to remarkable osteoclast activity, Bio-Oss(R) granules were cleared from the majority of biopsy cores. At histology, Fisiograft(R) gel appeared as globes enveloped by fibroblasts, displaying an epithelial-like cell appearance. Due to its solubility in solvents, undegraded Fisiograft(R) (recorded for 7 months or more) did not stain whereas degraded Fisiograft(R) stained positive. The loose connective tissue, that surrounded Fisiograft(R), and bone contained isolated mastocytes. Bone grew inside the loose connective and often reached the surface of Fisiograft(R) by intervening cells. The results seem to indicate that Fisiograft(R) may be considered both a polymer useful for fastening bone substitutes inside a defect and in addition a material capable of prompting bone regeneration, with or without the use of a bone substitute. In addition to space-former and space-maintainer functions, Fisiograft(R) shows potential bone stimulation function, which may be labelled as osteopromotive capability.

Histological study on sinus lift grafting by Fisiograft and Bio-Oss / Zaffe, Davide; Leghissa, Gc; Pradelli, J.; Botticelli, Ar. - In: JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE. - ISSN 0957-4530. - STAMPA. - 16(9):(2005), pp. 789-793. [10.1007/s10856-005-3574-5]

Histological study on sinus lift grafting by Fisiograft and Bio-Oss

ZAFFE, Davide;
2005

Abstract

The work aims to provide a histological investigation of Fisiograft(R) a PLA/PGA copolymer, used as filler for bone defects in humans. The study was performed on biopsies of sinus lifts where Bio-Oss(R) and Fisiograft(R) gel were applied as graft material. Bone regeneration was satisfactory in all sinus lifts, even when Fisiograft(R) was applied alone. Due to remarkable osteoclast activity, Bio-Oss(R) granules were cleared from the majority of biopsy cores. At histology, Fisiograft(R) gel appeared as globes enveloped by fibroblasts, displaying an epithelial-like cell appearance. Due to its solubility in solvents, undegraded Fisiograft(R) (recorded for 7 months or more) did not stain whereas degraded Fisiograft(R) stained positive. The loose connective tissue, that surrounded Fisiograft(R), and bone contained isolated mastocytes. Bone grew inside the loose connective and often reached the surface of Fisiograft(R) by intervening cells. The results seem to indicate that Fisiograft(R) may be considered both a polymer useful for fastening bone substitutes inside a defect and in addition a material capable of prompting bone regeneration, with or without the use of a bone substitute. In addition to space-former and space-maintainer functions, Fisiograft(R) shows potential bone stimulation function, which may be labelled as osteopromotive capability.
16(9)
789
793
Histological study on sinus lift grafting by Fisiograft and Bio-Oss / Zaffe, Davide; Leghissa, Gc; Pradelli, J.; Botticelli, Ar. - In: JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE. - ISSN 0957-4530. - STAMPA. - 16(9):(2005), pp. 789-793. [10.1007/s10856-005-3574-5]
Zaffe, Davide; Leghissa, Gc; Pradelli, J.; Botticelli, Ar
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/306184
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