Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS-associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.

Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors / Barozzi, Patrizia; Luppi, Mario; F., Facchetti; C., Mecucci; Alu, M.; R., Sarid; V., Rasini; L., Ravazzini; E., Rossi; S., Festa; B., Crescenzi; Dg, Wolf; Tf, Schulz; Torelli, Giuseppe. - In: NATURE MEDICINE. - ISSN 1078-8956. - STAMPA. - 9:5(2003), pp. 554-561. [10.1038/nm862]

Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors

BAROZZI, Patrizia;LUPPI, Mario;M. Alu;TORELLI, Giuseppe
2003

Abstract

Kaposi sarcoma (KS) is a vascular tumor that can develop in recipients of solid tissue transplants as a result of either primary infection or reactivation of a gammaherpesvirus, the KS-associated herpesvirus, also known as human herpesvirus-8 (HHV-8). We studied whether HHV-8 and the elusive KS progenitor cells could be transmitted from the donor through the grafts. We used a variety of molecular, cytogenetic, immunohistochemical and immunofluorescence methods to show that the HHV-8-infected neoplastic cells in post-transplant KS from five of eight renal transplant patients harbored either genetic or antigenic markers of their matched donors. These data suggest the use of donor-derived HHV-8-specific T cells for the control of post-transplant KS.
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Post-transplant Kaposi sarcoma originates from the seeding of donor-derived progenitors / Barozzi, Patrizia; Luppi, Mario; F., Facchetti; C., Mecucci; Alu, M.; R., Sarid; V., Rasini; L., Ravazzini; E., Rossi; S., Festa; B., Crescenzi; Dg, Wolf; Tf, Schulz; Torelli, Giuseppe. - In: NATURE MEDICINE. - ISSN 1078-8956. - STAMPA. - 9:5(2003), pp. 554-561. [10.1038/nm862]
Barozzi, Patrizia; Luppi, Mario; F., Facchetti; C., Mecucci; Alu, M.; R., Sarid; V., Rasini; L., Ravazzini; E., Rossi; S., Festa; B., Crescenzi; Dg, Wolf; Tf, Schulz; Torelli, Giuseppe
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/306172
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