Ifenprodil - an antagonist at the modulatory site of the NMDA receptor complex sensitive to polyamines - intraperitoneally injected at doses of 3 or 10 mg/kg, dose dependently prevented the behavioral syndrome induced by intracerebroventricular administration of adrenocorticotropin (ACTH)-(1-24) in adult male rats (excessive grooming, stretching, yawning, penile erections). These data further support a role of the brain ornithine decarboxylase (ODC)-polyamine system in the ACTH-induced behavioral syndrome, and may suggest an involvement of excitatory amino acids.
Influence of ifenprodil on the ACTH-induced behavioral syndrome in rats / Genedani, Susanna; M., Bernardi; Bertolini, Alfio. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 252:(1994), pp. 77-80.
Influence of ifenprodil on the ACTH-induced behavioral syndrome in rats
GENEDANI, Susanna;BERTOLINI, Alfio
1994-01-01
Abstract
Ifenprodil - an antagonist at the modulatory site of the NMDA receptor complex sensitive to polyamines - intraperitoneally injected at doses of 3 or 10 mg/kg, dose dependently prevented the behavioral syndrome induced by intracerebroventricular administration of adrenocorticotropin (ACTH)-(1-24) in adult male rats (excessive grooming, stretching, yawning, penile erections). These data further support a role of the brain ornithine decarboxylase (ODC)-polyamine system in the ACTH-induced behavioral syndrome, and may suggest an involvement of excitatory amino acids.
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