In a first series of experiments, different selective dopamine D2 receptor agonists (B-HT 920, B-HT 958, SND 919, CQ 32-084, CQP 201-403, and lisuride) and the D1/D2 agonist apomorphine were IP injected into adult male rats. At low doses, they elicited repeated episodes of penile erection and stretching-yawning; at all doses tested, B-HT 920, B-HT 958, and CQ 32-084 also induced hypomotility, a sign that, in the case of high doses of SND 919, CQP 201-403, lisuride, and apomorphine, was replaced by stereotyped behaviour. In a second series of experiments, the same D2 agonists and the mixed D1/D2 agonist apomorphine were IP injected at the same doses into chicks. The following behavioural signs were observed: hypomotility, sleep-like state, and stereotyped pecking. The results show that: 1. there are similarities between the behavioural effects induced by the DA agonists in rats and chicks; and 2. in both species some behavioural signs elicited by the DA ergic compounds are useful pointers to their specific neurochemical activity.

BEHAVIOURAL EFFECTS INDUCED IN RATS AND CHICKS BY D2 DOPAMINE AGONISTS / F., Ferrari; Giuliani, Daniela. - In: PHYSIOLOGY & BEHAVIOR. - ISSN 0031-9384. - STAMPA. - 54:(1993), pp. 695-700.

BEHAVIOURAL EFFECTS INDUCED IN RATS AND CHICKS BY D2 DOPAMINE AGONISTS

GIULIANI, Daniela
1993-01-01

Abstract

In a first series of experiments, different selective dopamine D2 receptor agonists (B-HT 920, B-HT 958, SND 919, CQ 32-084, CQP 201-403, and lisuride) and the D1/D2 agonist apomorphine were IP injected into adult male rats. At low doses, they elicited repeated episodes of penile erection and stretching-yawning; at all doses tested, B-HT 920, B-HT 958, and CQ 32-084 also induced hypomotility, a sign that, in the case of high doses of SND 919, CQP 201-403, lisuride, and apomorphine, was replaced by stereotyped behaviour. In a second series of experiments, the same D2 agonists and the mixed D1/D2 agonist apomorphine were IP injected at the same doses into chicks. The following behavioural signs were observed: hypomotility, sleep-like state, and stereotyped pecking. The results show that: 1. there are similarities between the behavioural effects induced by the DA agonists in rats and chicks; and 2. in both species some behavioural signs elicited by the DA ergic compounds are useful pointers to their specific neurochemical activity.
54
695
700
BEHAVIOURAL EFFECTS INDUCED IN RATS AND CHICKS BY D2 DOPAMINE AGONISTS / F., Ferrari; Giuliani, Daniela. - In: PHYSIOLOGY & BEHAVIOR. - ISSN 0031-9384. - STAMPA. - 54:(1993), pp. 695-700.
F., Ferrari; Giuliani, Daniela
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/305976
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