The cross-talk between neurons and glia is receiving increased attention because of its potential role in information processing in the nervous system. We choose the cluster of supramedullary neurons (SN) and glial cells of pufferfish as a suitable model for studying neuron-glial interactions, identifying the implicated cell types and the signalling involved. In particular, among pro-opiomelanocortin (POMC)-derived peptides, adrenocorticotrope hormone (ACTH)-immunopositivity was found both in SN and in microglial cells. The present results for the first time show the presence of ACTH in microglia of a vertebrate. The role of ACTH is discussed, including its possible neuroprotective function. Moreover, SN immunoreactivity supports the idea that ACTH participates in neurotransmission and/or neuromodulation. In addition to these possible functions, the hypothesis is put forward that ACTH represents a common language by which neurons and glial cells communicate with each other. (C) 2003 Elsevier Science (USA). All rights reserved.
|Data di pubblicazione:||2003|
|Titolo:||ACTH occurrence in teleosts supramedullary neuron clusters: a neuron-glial common language?|
|Autori:||B. Cuoghi; L. Blasiol; M.A. Sabatini|
|Autori interni:||CUOGHI, Barbara |
SABATINI, Maria Agnese
|Rivista:||GENERAL AND COMPARATIVE ENDOCRINOLOGY|
|Appare nelle tipologie:||Articolo su rivista|
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