A profound interrelationship between cytokines and invertebrate (molluscs) immune responses has been reported. Different cytokines (IL-1 alpha, IL-2 and TNF-alpha significantly stimulate molluscan hemocyte motility, increasing phagocytic activity and provoking the induction of nitric oxide synthase. As far as cell motility is concerned, the response to different cytokines varied between species. These and other recently reported findings (Ottaviani et al (1994) FEES Lett 351, 19-21; Ottaviani et al (1995) Biochem Biophys Res Commun 207, 288-292) suggest that cytokines are important, ancestral, and functionally conserved molecules, which have also maintained their pleiotropicity, redundancy in the mode of action, and high promiscuity of their receptors during evolution.
Cytokines and invertebrate immune responses / Ottaviani, Enzo; Franchini, Antonella; Cassanelli, Stefano; Genedani, Susanna. - In: BIOLOGY OF THE CELL. - ISSN 0248-4900. - STAMPA. - 85:(1995), pp. 87-91.
Cytokines and invertebrate immune responses
OTTAVIANI, Enzo;FRANCHINI, Antonella;CASSANELLI, Stefano;GENEDANI, Susanna
1995
Abstract
A profound interrelationship between cytokines and invertebrate (molluscs) immune responses has been reported. Different cytokines (IL-1 alpha, IL-2 and TNF-alpha significantly stimulate molluscan hemocyte motility, increasing phagocytic activity and provoking the induction of nitric oxide synthase. As far as cell motility is concerned, the response to different cytokines varied between species. These and other recently reported findings (Ottaviani et al (1994) FEES Lett 351, 19-21; Ottaviani et al (1995) Biochem Biophys Res Commun 207, 288-292) suggest that cytokines are important, ancestral, and functionally conserved molecules, which have also maintained their pleiotropicity, redundancy in the mode of action, and high promiscuity of their receptors during evolution.
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