A simple post-synthetic method for the preparation of 1,4,7-triazacyclononane-d(12) (90% atom D) is reported. The macrocycle is first converted into 1,4,7-trinitroso-1,4,7-triazacyclononane, whose solid-state and solution properties are herein described. In CD3OD/D2O solution, the trinitroso derivative undergoes fast base-catalyzed H,D exchange on the whole set of methylene hydrogens and can be subsequently denitrosated by reduction with Ni/Al alloy.

Post-synthetic Isotopic Labeling of an Azamacrocyclic Ligand / Pacchioni, Mirko; Bega, Andrea; FABRETTI COSTANTINO, Antonio; D., Rovai; Cornia, Andrea. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 43:(2002), pp. 771-774.

Post-synthetic Isotopic Labeling of an Azamacrocyclic Ligand

PACCHIONI, mirko;BEGA, Andrea;FABRETTI COSTANTINO, Antonio;CORNIA, Andrea
2002

Abstract

A simple post-synthetic method for the preparation of 1,4,7-triazacyclononane-d(12) (90% atom D) is reported. The macrocycle is first converted into 1,4,7-trinitroso-1,4,7-triazacyclononane, whose solid-state and solution properties are herein described. In CD3OD/D2O solution, the trinitroso derivative undergoes fast base-catalyzed H,D exchange on the whole set of methylene hydrogens and can be subsequently denitrosated by reduction with Ni/Al alloy.
43
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774
Post-synthetic Isotopic Labeling of an Azamacrocyclic Ligand / Pacchioni, Mirko; Bega, Andrea; FABRETTI COSTANTINO, Antonio; D., Rovai; Cornia, Andrea. - In: TETRAHEDRON LETTERS. - ISSN 0040-4039. - STAMPA. - 43:(2002), pp. 771-774.
Pacchioni, Mirko; Bega, Andrea; FABRETTI COSTANTINO, Antonio; D., Rovai; Cornia, Andrea
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/305901
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