In situ hybridization histochemistry of transverse sections from male rat kidney showed that the mRNA of the regulatory enzyme of polyamine degradation, spermidine/spermine N-1-acetyltransferase, has a spotty distribution in the cortex, is low and diffused in the outer stripe and high and diffused in the inner stripe of the outer medulla. At the cellular level, this mRNA is solely expressed by the epithelium of the distal straight and convoluted nephron tubules, Since biosynthetic ornithine decarboxylase mRNA is solely found in the proximal straight tubules, it is proposed that polyamine biosynthesis and degradation occur at separate sites along the nephron.
Different localization of spermidine spermine N-1-acetyltransferase and ornithine decarboxylase transcripts in the rat kidney / S., Bettuzzi; M., Marinelli; P., Strocchi; Davalli, Pierpaola; D., Cevolani; Corti, Arnaldo. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 377:(1995), pp. 321-324.
Different localization of spermidine spermine N-1-acetyltransferase and ornithine decarboxylase transcripts in the rat kidney
DAVALLI, Pierpaola;CORTI, Arnaldo
1995
Abstract
In situ hybridization histochemistry of transverse sections from male rat kidney showed that the mRNA of the regulatory enzyme of polyamine degradation, spermidine/spermine N-1-acetyltransferase, has a spotty distribution in the cortex, is low and diffused in the outer stripe and high and diffused in the inner stripe of the outer medulla. At the cellular level, this mRNA is solely expressed by the epithelium of the distal straight and convoluted nephron tubules, Since biosynthetic ornithine decarboxylase mRNA is solely found in the proximal straight tubules, it is proposed that polyamine biosynthesis and degradation occur at separate sites along the nephron.Pubblicazioni consigliate
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