Solid dispersions of diflunisal (DIF) with Eudragit RS100 (RS) and RL100 (RL) with different drug-to-polymer ratios were prepared by a solvent method (coevaporates) and were characterised in the solid state in comparison with the corresponding physical mixtures. The work was aimed at characterising the interactions occurring between DIF and RS or RL polymers, along with their influence on the in-vitro drug-dissolution pattern. The findings suggest that the drug did not change its crystalline form within the polymer network. Drug dispersion in the polymer matrix strongly influences its dissolution rate, which appears slower and more gradual while increasing the polymer ratios. Moreover, DIF is known to be a photosensitive compound, and its photoproduct has been found to be a toxic agent. This can be evidenced by testing red blood cell membranes for their resistance to the osmotic shock induced by UVA irradiation in the presence of DIF. The presence of some DIF/RS coevaporates was shown to reduce significantly the drug photosensitization process towards cell membranes. This suggests the possibility of combining the design of a drug delivery system with a photoprotective strategy. (C) 2001 Elsevier Science B.V. All rights reserved.

Preparation, characterisation and photosensitivity studies of solid dispersions of diflunisal and Eudragit RS100 (R) and RL100 (R) / R., Pignatello; M., Ferro; G., De Guidi; G., Salemi; Vandelli, Maria Angela; S., Guccione; M., Geppi; C., Forte; G., Puglisi. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - STAMPA. - 218(2001), pp. 27-42.

Preparation, characterisation and photosensitivity studies of solid dispersions of diflunisal and Eudragit RS100 (R) and RL100 (R)

VANDELLI, Maria Angela;
2001

Abstract

Solid dispersions of diflunisal (DIF) with Eudragit RS100 (RS) and RL100 (RL) with different drug-to-polymer ratios were prepared by a solvent method (coevaporates) and were characterised in the solid state in comparison with the corresponding physical mixtures. The work was aimed at characterising the interactions occurring between DIF and RS or RL polymers, along with their influence on the in-vitro drug-dissolution pattern. The findings suggest that the drug did not change its crystalline form within the polymer network. Drug dispersion in the polymer matrix strongly influences its dissolution rate, which appears slower and more gradual while increasing the polymer ratios. Moreover, DIF is known to be a photosensitive compound, and its photoproduct has been found to be a toxic agent. This can be evidenced by testing red blood cell membranes for their resistance to the osmotic shock induced by UVA irradiation in the presence of DIF. The presence of some DIF/RS coevaporates was shown to reduce significantly the drug photosensitization process towards cell membranes. This suggests the possibility of combining the design of a drug delivery system with a photoprotective strategy. (C) 2001 Elsevier Science B.V. All rights reserved.
218
27
42
Preparation, characterisation and photosensitivity studies of solid dispersions of diflunisal and Eudragit RS100 (R) and RL100 (R) / R., Pignatello; M., Ferro; G., De Guidi; G., Salemi; Vandelli, Maria Angela; S., Guccione; M., Geppi; C., Forte; G., Puglisi. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - STAMPA. - 218(2001), pp. 27-42.
R., Pignatello; M., Ferro; G., De Guidi; G., Salemi; Vandelli, Maria Angela; S., Guccione; M., Geppi; C., Forte; G., Puglisi
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/305856
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