Non-organ-specific autoantibodies in nonalcoholic fatty liver disease: Prevalence and correlates

Loria, Paola; Lonardo, A.; Leonardi, F.; Fontana, C.; Carulli, Lucia; Verrone, Am; Borsatti, A.; Bertolotti, Marco; Cassani, F.; Bagni, A.; Muratori, P.; Ganazzi, D.; Bianchi, Fb; Carulli, N.

Eighty-four consecutive subjects with nonalcoholic fatty liver disease (NAFLD) were tested for non-organ-specific autoantibodies (NOSA) by indirect immunoflorescence. Indices of insulin resistance and biochemical and anthropometric parameters were assessed. The overall prevalence of anti-nuclear-antibodies (ANA), smooth muscle antibodies (SMA) and anti-mitochondrial-antibodies (AMA) was 35.7% (30/84), 18 subjects (21.4%) being positive for ANA, 4 (4.7%) for SMA, 6 for ANA and SMA, and 2 for AMA. NOSA-positive subjects were older (P < 0.01) and mostly females (63.3%). No significant difference was found in the age-corrected parameters studied, except for copper and ceruloplasmin, which was more elevated in NOSA-positive patients. The subset of high titer (&GE;1:100) ANA-positive patients had significantly (P < 0.05) greater insulin resistance than ANA-negative patients. In contrast, SMA-positive patients had higher gammaglobulin and significantly lower insulin resistance as compared to high-titer ANA-positive patients. In 3 NOSA-positive but not in NOSA-negative patients, liver biopsy disclosed features of overlapping NASH with autoimmune hepatitis, partially responding to diet combined with steroid treatment. In conclusion, NOSA positivity in NAFLD is more prevalent than in the general population. High-titre ANA but not SMA positivity is associated with insulin resistance.

Non-organ-specific autoantibodies in nonalcoholic fatty liver disease: Prevalence and correlates / Loria, Paola; A., Lonardo; F., Leonardi; C., Fontana; Carulli, Lucia; Am, Verrone; A., Borsatti; Bertolotti, Marco; F., Cassani; A., Bagni; P., Muratori; D., Ganazzi; Fb, Bianchi; N., Carulli. - In: DIGESTIVE DISEASES AND SCIENCES. - ISSN 0163-2116. - ELETTRONICO. - 48(2003), pp. 2173-2181.

Data di pubblicazione:	2003
Titolo:	Non-organ-specific autoantibodies in nonalcoholic fatty liver disease: Prevalence and correlates
Autore/i:	Loria, Paola; A., Lonardo; F., Leonardi; C., Fontana; Carulli, Lucia; Am, Verrone; A., Borsatti; Bertolotti, Marco; F., Cassani; A., Bagni; P., Muratori; D., Ganazzi; Fb, Bianchi; N., Carulli
Autore/i UNIMORE:	LORIA, Paola A. Lonardo F. Leonardi C. Fontana CARULLI, Lucia AM Verrone A. Borsatti BERTOLOTTI, Marco F. Cassani A. Bagni P. Muratori D. Ganazzi FB Bianchi N. Carulli mostra contributor esterni nascondi contributor esterni
Rivista:	DIGESTIVE DISEASES AND SCIENCES
Volume:	48
Pagina iniziale:	2173
Pagina finale:	2181
Codice identificativo ISI:	WOS:000186661000010
Codice identificativo Scopus:	2-s2.0-9144258000
Codice identificativo Pubmed:	14705824
Citazione:	Non-organ-specific autoantibodies in nonalcoholic fatty liver disease: Prevalence and correlates / Loria, Paola; A., Lonardo; F., Leonardi; C., Fontana; Carulli, Lucia; Am, Verrone; A., Borsatti; Bertolotti, Marco; F., Cassani; A., Bagni; P., Muratori; D., Ganazzi; Fb, Bianchi; N., Carulli. - In: DIGESTIVE DISEASES AND SCIENCES. - ISSN 0163-2116. - ELETTRONICO. - 48(2003), pp. 2173-2181.
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