A 53-yr-old man, a member of a hereditary nonpolyposis colorectal cancer (HNPCC) family, with previous colonoscopic polypectomies, presented for persisting vomiting and marked signs of dehydration. Previous radiological and endoscopic examinations of the upper digestive tract were negative, with the exception of the presence of a duodenal adenomatous polyp. Enteroclysis led to a diagnosis of obstruction at the Treitz angle due to a moderately differentiated adenocarcinoma, Microsatellite instability was demonstrated in the DNA extracted from the tumor. The patient was the carrier of a mutation in the intron 13 of the hMLH1 gene, one of the four mismatch repair genes known to be responsible for HNPCC.

Small bowel carcinoma in hereditary nonpolyposis colorectal cancer / Benatti, Piero; Roncucci, Luca; Percesepe, Antonio; A., Viel; Pedroni, Monica; Mg, Tamassia; F., Vaccina; R., Fante; S., De Pietri; PONZ DE LEON, Maurizio. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - ELETTRONICO. - 93:(1998), pp. 2219-2222.

Small bowel carcinoma in hereditary nonpolyposis colorectal cancer

BENATTI, Piero;RONCUCCI, Luca;PERCESEPE, Antonio;PEDRONI, Monica;PONZ DE LEON, Maurizio
1998

Abstract

A 53-yr-old man, a member of a hereditary nonpolyposis colorectal cancer (HNPCC) family, with previous colonoscopic polypectomies, presented for persisting vomiting and marked signs of dehydration. Previous radiological and endoscopic examinations of the upper digestive tract were negative, with the exception of the presence of a duodenal adenomatous polyp. Enteroclysis led to a diagnosis of obstruction at the Treitz angle due to a moderately differentiated adenocarcinoma, Microsatellite instability was demonstrated in the DNA extracted from the tumor. The patient was the carrier of a mutation in the intron 13 of the hMLH1 gene, one of the four mismatch repair genes known to be responsible for HNPCC.
93
2219
2222
Small bowel carcinoma in hereditary nonpolyposis colorectal cancer / Benatti, Piero; Roncucci, Luca; Percesepe, Antonio; A., Viel; Pedroni, Monica; Mg, Tamassia; F., Vaccina; R., Fante; S., De Pietri; PONZ DE LEON, Maurizio. - In: THE AMERICAN JOURNAL OF GASTROENTEROLOGY. - ISSN 0002-9270. - ELETTRONICO. - 93:(1998), pp. 2219-2222.
Benatti, Piero; Roncucci, Luca; Percesepe, Antonio; A., Viel; Pedroni, Monica; Mg, Tamassia; F., Vaccina; R., Fante; S., De Pietri; PONZ DE LEON, Maurizio
File in questo prodotto:
File Dimensione Formato  
Benatti 1998.pdf

non disponibili

Tipologia: Post-print dell'autore (bozza post referaggio)
Dimensione 321.25 kB
Formato Adobe PDF
321.25 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/305793
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 17
  • ???jsp.display-item.citation.isi??? 17
social impact