The effect of alpha-difluoromethylornithine (alpha-DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC) the rate limiting enzyme of polyamine biosynthesis, was studied on the astroglial reaction in a model of mechanical brain injury. alpha-DFMO markedly decreased the astroglial activation induced by the microdialysis probe implantation in the striatum of the male rat, as studied by glial fibrillary acidic protein (GFAP) immunocytochemistry. This response was restored by putrescine (20 nmol/ml) administered via the microdialysis probe. These results suggest that the astroglial reaction and the polyamine biosynthesis activation induced by a localized mechanical lesion are causally linked phenomena.

Evidence for a role of neosynthetized putrescine in the increase of glial fibrillary acid protein immunoreactivity induced by a mechanical lesion in the rat brain / Zini, Isabella; Zoli, Michele; R., Grimaldi; MERLO PICH, Emilio; Biagini, Giuseppe; K., Fuxe; Agnati, Luigi Francesco. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 120:(1990), pp. 13-16.

Evidence for a role of neosynthetized putrescine in the increase of glial fibrillary acid protein immunoreactivity induced by a mechanical lesion in the rat brain

ZINI, Isabella;ZOLI, Michele;MERLO PICH, Emilio;BIAGINI, Giuseppe;AGNATI, Luigi Francesco
1990

Abstract

The effect of alpha-difluoromethylornithine (alpha-DFMO), an irreversible inhibitor of ornithine decarboxylase (ODC) the rate limiting enzyme of polyamine biosynthesis, was studied on the astroglial reaction in a model of mechanical brain injury. alpha-DFMO markedly decreased the astroglial activation induced by the microdialysis probe implantation in the striatum of the male rat, as studied by glial fibrillary acidic protein (GFAP) immunocytochemistry. This response was restored by putrescine (20 nmol/ml) administered via the microdialysis probe. These results suggest that the astroglial reaction and the polyamine biosynthesis activation induced by a localized mechanical lesion are causally linked phenomena.
120
13
16
Evidence for a role of neosynthetized putrescine in the increase of glial fibrillary acid protein immunoreactivity induced by a mechanical lesion in the rat brain / Zini, Isabella; Zoli, Michele; R., Grimaldi; MERLO PICH, Emilio; Biagini, Giuseppe; K., Fuxe; Agnati, Luigi Francesco. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 120:(1990), pp. 13-16.
Zini, Isabella; Zoli, Michele; R., Grimaldi; MERLO PICH, Emilio; Biagini, Giuseppe; K., Fuxe; Agnati, Luigi Francesco
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/305758
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