Acetylsalicylic acid (ASA), 400 mg/kg i.p., displayed antinociceptive activity in both the hot-plate and the formalin test, ASA significantly increased brain serotonin (5-HT) content and reduced the number of 5-HT2 receptors in cortical brain membranes 30 min after drug administration, Pretreatment with naloxone abolished the antinociceptive activity of both ASA and morphine in the hot-plate and formalin tests and prevented the increase in cerebral 5-HT concentration and the reduction in 5-HT2 receptors in cortical membranes induced by ASA, The serum salicylate concentrations were not affected by pretreatment with naloxone, These data indicate a central antinociceptive activity of ASA and suggest that ASA may exert its antinociceptive action through serotonergic and opiatergic pathways.

Serotonin and opiate involvement in the antinociceptive effect of acetylsalicylic acid / Pini, Luigi Alberto; Vitale, Giovanni; Sandrini, Maurizio. - In: PHARMACOLOGY. - ISSN 0031-7012. - STAMPA. - 54:(1997), pp. 84-91.

Serotonin and opiate involvement in the antinociceptive effect of acetylsalicylic acid

PINI, Luigi Alberto;VITALE, Giovanni;SANDRINI, Maurizio
1997

Abstract

Acetylsalicylic acid (ASA), 400 mg/kg i.p., displayed antinociceptive activity in both the hot-plate and the formalin test, ASA significantly increased brain serotonin (5-HT) content and reduced the number of 5-HT2 receptors in cortical brain membranes 30 min after drug administration, Pretreatment with naloxone abolished the antinociceptive activity of both ASA and morphine in the hot-plate and formalin tests and prevented the increase in cerebral 5-HT concentration and the reduction in 5-HT2 receptors in cortical membranes induced by ASA, The serum salicylate concentrations were not affected by pretreatment with naloxone, These data indicate a central antinociceptive activity of ASA and suggest that ASA may exert its antinociceptive action through serotonergic and opiatergic pathways.
54
84
91
Serotonin and opiate involvement in the antinociceptive effect of acetylsalicylic acid / Pini, Luigi Alberto; Vitale, Giovanni; Sandrini, Maurizio. - In: PHARMACOLOGY. - ISSN 0031-7012. - STAMPA. - 54:(1997), pp. 84-91.
Pini, Luigi Alberto; Vitale, Giovanni; Sandrini, Maurizio
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/305596
Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 22
social impact