The effect of the D2 agonist B-HT 920 was examined on three behavioural models of induced grooming in the rat. B-HT 920 potently inhibited the grooming elicited by a novel environment, whereas it stimulated the stretching-yawning syndrome. Pretreatment with the selective dopamine D2 receptor antagonist, sulpiride, reversed the phenomenon. When B-HT 920 was administered to rats before water immersion, it similarly antagonized total grooming; wet-dog shakes, detected in these same animals, were potently inhibited. Finally, B-HT 920 displayed inhibitory activity towards adrenocorticotropin hormone-induced excessive rooming. On the basis of these effects, the role of D2 receptor subtypes in the modulation of grooming is discussed.
SUPPRESSIVE EFFECT OF THE DOPAMINE D2-RECEPTOR AGONIST B-HT 920 ON RAT GROOMING / F., F., F., P., Giuliani, D.. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 216:(1992), pp. 345-350. [10.1016/0014-2999(92)90429-6]
SUPPRESSIVE EFFECT OF THE DOPAMINE D2-RECEPTOR AGONIST B-HT 920 ON RAT GROOMING
GIULIANI, Daniela
1992
Abstract
The effect of the D2 agonist B-HT 920 was examined on three behavioural models of induced grooming in the rat. B-HT 920 potently inhibited the grooming elicited by a novel environment, whereas it stimulated the stretching-yawning syndrome. Pretreatment with the selective dopamine D2 receptor antagonist, sulpiride, reversed the phenomenon. When B-HT 920 was administered to rats before water immersion, it similarly antagonized total grooming; wet-dog shakes, detected in these same animals, were potently inhibited. Finally, B-HT 920 displayed inhibitory activity towards adrenocorticotropin hormone-induced excessive rooming. On the basis of these effects, the role of D2 receptor subtypes in the modulation of grooming is discussed.
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