The effect of the D2 agonist B-HT 920 was examined on three behavioural models of induced grooming in the rat. B-HT 920 potently inhibited the grooming elicited by a novel environment, whereas it stimulated the stretching-yawning syndrome. Pretreatment with the selective dopamine D2 receptor antagonist, sulpiride, reversed the phenomenon. When B-HT 920 was administered to rats before water immersion, it similarly antagonized total grooming; wet-dog shakes, detected in these same animals, were potently inhibited. Finally, B-HT 920 displayed inhibitory activity towards adrenocorticotropin hormone-induced excessive rooming. On the basis of these effects, the role of D2 receptor subtypes in the modulation of grooming is discussed.

SUPPRESSIVE EFFECT OF THE DOPAMINE D2-RECEPTOR AGONIST B-HT 920 ON RAT GROOMING / F., Ferrari; F., Pelloni; Giuliani, Daniela. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 216:(1992), pp. 345-350.

SUPPRESSIVE EFFECT OF THE DOPAMINE D2-RECEPTOR AGONIST B-HT 920 ON RAT GROOMING

GIULIANI, Daniela
1992

Abstract

The effect of the D2 agonist B-HT 920 was examined on three behavioural models of induced grooming in the rat. B-HT 920 potently inhibited the grooming elicited by a novel environment, whereas it stimulated the stretching-yawning syndrome. Pretreatment with the selective dopamine D2 receptor antagonist, sulpiride, reversed the phenomenon. When B-HT 920 was administered to rats before water immersion, it similarly antagonized total grooming; wet-dog shakes, detected in these same animals, were potently inhibited. Finally, B-HT 920 displayed inhibitory activity towards adrenocorticotropin hormone-induced excessive rooming. On the basis of these effects, the role of D2 receptor subtypes in the modulation of grooming is discussed.
1992
216
345
350
SUPPRESSIVE EFFECT OF THE DOPAMINE D2-RECEPTOR AGONIST B-HT 920 ON RAT GROOMING / F., Ferrari; F., Pelloni; Giuliani, Daniela. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 216:(1992), pp. 345-350.
F., Ferrari; F., Pelloni; Giuliani, Daniela
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/305452
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