EnglishThe mGluR5 antagonist MPEP was used to study the role of mGluR5 in MPTP-induced injury of the nigrostriatal DA neurons. The findings indicate that acute blockade of mGluR5 may result in neuroprotective actions against MPTP neurotoxicity on nigral DA cell bodies and striatal DA terminals using stereological analysis of TH immunoreactivity and microdensitometry. Biochemical analysis showed no restoration of DA levels and metabolism indicating a maintained reduction of DA transmission.
Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP / J. A., Aguirre; J., Kehr; T., Yoshitake; F. L., Liu; A., Rivera; S., Fernandez Espinola; B., Andbjer; Leo, Giuseppina; A. D., Medhurst; Agnati, Luigi Francesco; K., Fuxe. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 1033(2005), pp. 216-220.
| Data di pubblicazione: | 2005 | |
| Titolo: | Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP | |
| Autore/i: | J. A., Aguirre; J., Kehr; T., Yoshitake; F. L., Liu; A., Rivera; S., Fernandez Espinola; B., Andbjer; Leo, Giuseppina; A. D., Medhurst; Agnati, Luigi Francesco; K., Fuxe | |
| Autore/i UNIMORE: | ||
| Rivista: | ||
| Volume: | 1033 | |
| Pagina iniziale: | 216 | |
| Pagina finale: | 220 | |
| Codice identificativo ISI: | WOS:000227144000013 | |
| Codice identificativo Scopus: | 2-s2.0-19944430985 | |
| Codice identificativo Pubmed: | 15694927 | |
| Citazione: | Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP / J. A., Aguirre; J., Kehr; T., Yoshitake; F. L., Liu; A., Rivera; S., Fernandez Espinola; B., Andbjer; Leo, Giuseppina; A. D., Medhurst; Agnati, Luigi Francesco; K., Fuxe. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 1033(2005), pp. 216-220. | |
| Tipologia | Articolo su rivista |
File in questo prodotto:
Pubblicazioni consigliate
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
Copyright © 2021