We investigated 22 patients with migraine without aura, all drug-free and in headache-free periods, by means of P-31-magnetic resonance spectroscopy (MRS) of brain and muscle. Brain P-31-MRS showed significantly low phosphocreatine, increased adenosine diphosphate, and decreased phosphorylation potential. There was a slow rate of phosphocreatine recovery after exercise in the muscle of 12 of 22 patients. Energy metabolism is abnormal in migraine without aura, as previously demonstrated in patients with migraine stroke and migraine with aura.
P-31-MAGNETIC RESONANCE SPECTROSCOPY IN MIGRAINE WITHOUT AURA / P., Montagna; P., Cortelli; L., Monari; G., Pierangeli; P., Parchi; R., Lodi; S., Iotti; Frassineti, Chiara; Zaniol, Paolo; E., Lugaresi; B., Barbiroli. - In: NEUROLOGY. - ISSN 0028-3878. - STAMPA. - 44:(1994), pp. 666-669.
P-31-MAGNETIC RESONANCE SPECTROSCOPY IN MIGRAINE WITHOUT AURA
FRASSINETI, Chiara;ZANIOL, Paolo;
1994
Abstract
We investigated 22 patients with migraine without aura, all drug-free and in headache-free periods, by means of P-31-magnetic resonance spectroscopy (MRS) of brain and muscle. Brain P-31-MRS showed significantly low phosphocreatine, increased adenosine diphosphate, and decreased phosphorylation potential. There was a slow rate of phosphocreatine recovery after exercise in the muscle of 12 of 22 patients. Energy metabolism is abnormal in migraine without aura, as previously demonstrated in patients with migraine stroke and migraine with aura.
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