A significant broad substrate specificity, that crosses over the usual beta-lactam derivatives, has been observed with an industrial glutaryl-7-aminocephalosporanic acid acylase (GA). This enzyme possesses significant enantioselective amidase and even esterase activity, with a stereopreference for the S-enantiomer. The easy separation of products from unreacted reagents, possessing different physical-chemical properties, is achieved by solvent extraction, avoiding chromatography or distillation during reaction work-up.
Glutaryl acylases: One-reaction enzymes or versatile enantioselective biocatalysts? / Raimondi, S.; Monti, D.; Pagnoni, Ugo Maria; Riva, S.. - In: ADVANCED SYNTHESIS & CATALYSIS. - ISSN 1615-4150. - 345:6-7(2003), pp. 783-789. [10.1002/adsc.200303013]
Glutaryl acylases: One-reaction enzymes or versatile enantioselective biocatalysts?
S. Raimondi;PAGNONI, Ugo Maria;
2003
Abstract
A significant broad substrate specificity, that crosses over the usual beta-lactam derivatives, has been observed with an industrial glutaryl-7-aminocephalosporanic acid acylase (GA). This enzyme possesses significant enantioselective amidase and even esterase activity, with a stereopreference for the S-enantiomer. The easy separation of products from unreacted reagents, possessing different physical-chemical properties, is achieved by solvent extraction, avoiding chromatography or distillation during reaction work-up.
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