EnglishAn industrial glutaryl-7-aminocephalosporanic acid acylase (GAR) possesses a significant broad substrate specificity that crosses over the usual cephalosporanic skeleton. Enantioselective amidase and even esterase activities have been observed with all the glutarates of racemic substrates investigated, with a stereopreference for the (S)-enantiomer. The different physical-chemical properties of reagents and products allow their easy separation by solvent extraction, avoiding cumbersome chromatography or distillation processes during reaction work-up. (C) 2003 Elsevier Science Ltd. All rights reserved.
Kinetic resolutions of racemic amines and alcohols catalyzed by an industrial glutaryl-7-aminocephalosporanic acid acylase with unexpected broad substrate specificity / Raimondi, Stefano; Forti, Luca; D., Monti; S., Riva. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 14(2003), pp. 1091-1094. [10.1016/S0957-4166(03)00171-X]
| Data di pubblicazione: | 2003 | |
| Titolo: | Kinetic resolutions of racemic amines and alcohols catalyzed by an industrial glutaryl-7-aminocephalosporanic acid acylase with unexpected broad substrate specificity | |
| Autore/i: | Raimondi, Stefano; Forti, Luca; D., Monti; S., Riva | |
| Autore/i UNIMORE: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0957-4166(03)00171-X | |
| Rivista: | ||
| Volume: | 14 | |
| Pagina iniziale: | 1091 | |
| Pagina finale: | 1094 | |
| Codice identificativo ISI: | WOS:000182637600003 | |
| Codice identificativo Scopus: | 2-s2.0-0344519693 | |
| Citazione: | Kinetic resolutions of racemic amines and alcohols catalyzed by an industrial glutaryl-7-aminocephalosporanic acid acylase with unexpected broad substrate specificity / Raimondi, Stefano; Forti, Luca; D., Monti; S., Riva. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - STAMPA. - 14(2003), pp. 1091-1094. [10.1016/S0957-4166(03)00171-X] | |
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