Spray-dried and spray-embedded ethylcellulose microparticles were prepared using a spray-drying technique. The structure of the microparticles (microcapsules or microspheres) changed according to whether the drug (diltiazem hydrochloride) was dispersed or dissolved in the ethylcellulose solution to be spray-dried. The drug release rate from the microparticles was not affected by the physical state of the drug (amorphous or crystalline state), but by the microparticle structure.
Drug release from spray-dried and spray-embedded microparticles of diltiazem hydrochloride / Forni, Flavio; Coppi, Gilberto; Vandelli, Maria Angela; R., Cameroni. - In: CHEMICAL & PHARMACEUTICAL BULLETIN. - ISSN 0009-2363. - STAMPA. - 39:(1991), pp. 2091-2095.
Drug release from spray-dried and spray-embedded microparticles of diltiazem hydrochloride
FORNI, Flavio;COPPI, Gilberto;VANDELLI, Maria Angela;
1991
Abstract
Spray-dried and spray-embedded ethylcellulose microparticles were prepared using a spray-drying technique. The structure of the microparticles (microcapsules or microspheres) changed according to whether the drug (diltiazem hydrochloride) was dispersed or dissolved in the ethylcellulose solution to be spray-dried. The drug release rate from the microparticles was not affected by the physical state of the drug (amorphous or crystalline state), but by the microparticle structure.
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