Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis is unknown. Status epilepticus (SE) induces temporal lobe epileptogenesis following a latent period in which glial cells are activated. Here, we found that P450scc, the rate-limiting enzyme in steroid synthesis.. is upregulated in hippocampal glia during the latent period after pilocarpine-induced SE in rats. More prolonged SE was associated with greater P450scc expression and longer latencies to the development of seizures, suggesting that enhanced steroid synthesis retards epileptogenesis. The 5 alpha-reductase inhibitor finasteride, which blocks neurosteroid synthesis, reduced the latent period, indicating that glia-derived neurosteroids may be antiepileptogenic. (c) 2006 Elsevier Inc. All rights reserved.

Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy / Biagini, Giuseppe; Baldelli, Enrica; Longo, Daniela; L., Pradelli; Zini, Isabella; M. A., Rogawski; M., Avoli. - In: EXPERIMENTAL NEUROLOGY. - ISSN 0014-4886. - STAMPA. - 201:2(2006), pp. 519-524. [10.1016/j.expneurol.2006.04.029]

Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy

BIAGINI, Giuseppe;BALDELLI, Enrica;LONGO, Daniela;ZINI, Isabella;
2006

Abstract

Neurosteroids modulate seizure susceptibility, but their role in the regulation of epileptogenesis is unknown. Status epilepticus (SE) induces temporal lobe epileptogenesis following a latent period in which glial cells are activated. Here, we found that P450scc, the rate-limiting enzyme in steroid synthesis.. is upregulated in hippocampal glia during the latent period after pilocarpine-induced SE in rats. More prolonged SE was associated with greater P450scc expression and longer latencies to the development of seizures, suggesting that enhanced steroid synthesis retards epileptogenesis. The 5 alpha-reductase inhibitor finasteride, which blocks neurosteroid synthesis, reduced the latent period, indicating that glia-derived neurosteroids may be antiepileptogenic. (c) 2006 Elsevier Inc. All rights reserved.
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Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy / Biagini, Giuseppe; Baldelli, Enrica; Longo, Daniela; L., Pradelli; Zini, Isabella; M. A., Rogawski; M., Avoli. - In: EXPERIMENTAL NEUROLOGY. - ISSN 0014-4886. - STAMPA. - 201:2(2006), pp. 519-524. [10.1016/j.expneurol.2006.04.029]
Biagini, Giuseppe; Baldelli, Enrica; Longo, Daniela; L., Pradelli; Zini, Isabella; M. A., Rogawski; M., Avoli
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/304972
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