Chiral conformations of flexible molecules may develop in a concerted manner if the molecule is crowded enough to assure sufficient level of through-the-space contacts. Higher number (>4) of groups connected to the same atom, as in many coordination compounds, can be advantageous in this resp ect. The case study of R,S-[(sec-butoxycarbonyl)methyl]cobalt tricarbonyl triphenylphosphine is presented here. X-ray diffraction shows that the possible number of enantiomeric and diastereomeric conformations is reduced by 75% (from 8 to 2) by concerted development of the molecular conformations in crystalline phase.
Diastereoselection through chiral conformations / M., Szabo; R., Szilagyi; L., Bencze; R., Boese; C., Zucchi; L., Caglioti; Palyi, Gyula. - In: ENANTIOMER. - ISSN 1024-2430. - 5:6(2000), pp. 549-559.
Diastereoselection through chiral conformations
PALYI, Gyula
2000
Abstract
Chiral conformations of flexible molecules may develop in a concerted manner if the molecule is crowded enough to assure sufficient level of through-the-space contacts. Higher number (>4) of groups connected to the same atom, as in many coordination compounds, can be advantageous in this resp ect. The case study of R,S-[(sec-butoxycarbonyl)methyl]cobalt tricarbonyl triphenylphosphine is presented here. X-ray diffraction shows that the possible number of enantiomeric and diastereomeric conformations is reduced by 75% (from 8 to 2) by concerted development of the molecular conformations in crystalline phase.
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