Hypothalamic mRNA and peptide levels of pro-opio-melanocortin (POMC) and other neuropeptides were studied in rats that either develop obesity (diet-induced obese, DIO), when fed a palatable and hypercaloric diet (cafeteria diet, caf) or do not develop obesity (diet resistant, DR), when fed the same diet. cafDIO rats showed a significant increase in POMC, but not in melanin concentrating hormone, mRNA levels as determined by semiquantitative in situ hybridization. cafDR and cafDIO rats showed no change in POMC-derived peptide levels, whereas neuropeptide Y immunoreactivity was significantly increased in cafDR rats. POW mRNA levels were also studied in high-fat diet-fed rats but no significant change was observed. Altered hypothalamic transmission by POMC-derived peptides may contribute to the susceptibility of cafDIO rats to the weight promoting action of caf diet.
Diet-induced changes in hypothalamic pro-opio-melanocortin mRNA in the rat hypothalamus / C., Torri; Pedrazzi, Patrizia; Leo, Giuseppina; E. E., Muller; D., Cocchi; Agnati, Luigi Francesco; Zoli, Michele. - In: PEPTIDES. - ISSN 0196-9781. - STAMPA. - 23:6(2002), pp. 1063-1068. [10.1016/S0196-9781(02)00030-X]
Diet-induced changes in hypothalamic pro-opio-melanocortin mRNA in the rat hypothalamus
PEDRAZZI, Patrizia;LEO, Giuseppina;AGNATI, Luigi Francesco;ZOLI, Michele
2002
Abstract
Hypothalamic mRNA and peptide levels of pro-opio-melanocortin (POMC) and other neuropeptides were studied in rats that either develop obesity (diet-induced obese, DIO), when fed a palatable and hypercaloric diet (cafeteria diet, caf) or do not develop obesity (diet resistant, DR), when fed the same diet. cafDIO rats showed a significant increase in POMC, but not in melanin concentrating hormone, mRNA levels as determined by semiquantitative in situ hybridization. cafDR and cafDIO rats showed no change in POMC-derived peptide levels, whereas neuropeptide Y immunoreactivity was significantly increased in cafDR rats. POW mRNA levels were also studied in high-fat diet-fed rats but no significant change was observed. Altered hypothalamic transmission by POMC-derived peptides may contribute to the susceptibility of cafDIO rats to the weight promoting action of caf diet.
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