General and cardiac toxicity of doxorubicin loaded gelatin nanoparticles cross-linked by glutaraldheyde were investigated in healthy rats. The rats were treated with free doxorubicin (DXR), unloaded nanoparticles (UNp), physical mixture of doxorubicin, and unloaded nanoparticles (DRX/UNp), and DXR-loaded nanoparticles (DXR-Np). Each group of animals received the same dose of DXR (3 mg/kg) via i.p. once a week. Both electrocardiogram (EGG) parameters and body weight were measured 24h before each administration. Rats treated with UNp behaved as controls. DXR/UNp provoked the same toxic effects as free DXR. On the contrary, DXR-Np resulted more toxic since significant variations of both the body weight and the ECG parameters were observed during the first week of treatment. In addition, the rats treated with DXR-Np died between the 3(rd) and the 5(th) day after the 2(nd) administration. These results demonstrate that, in these experimental conditions, the couplage of DXR to nanoparticles enhanced the cardiotoxicity of the drug. Since DXR was linked to the protein matrix of nanoparticles via glutaraldehyde, the high toxicity of DXR-loaded nanoparticles could be due to the covalent binding of the drug to the carrier.

General and cardiac toxicity of doxorubicin-loaded gelatin nanoparticles / Leo, Eliana Grazia; R., Arletti; Forni, Flavio; R., Cameroni. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 52:(1997), pp. 385-388.

General and cardiac toxicity of doxorubicin-loaded gelatin nanoparticles

LEO, Eliana Grazia;FORNI, Flavio;
1997

Abstract

General and cardiac toxicity of doxorubicin loaded gelatin nanoparticles cross-linked by glutaraldheyde were investigated in healthy rats. The rats were treated with free doxorubicin (DXR), unloaded nanoparticles (UNp), physical mixture of doxorubicin, and unloaded nanoparticles (DRX/UNp), and DXR-loaded nanoparticles (DXR-Np). Each group of animals received the same dose of DXR (3 mg/kg) via i.p. once a week. Both electrocardiogram (EGG) parameters and body weight were measured 24h before each administration. Rats treated with UNp behaved as controls. DXR/UNp provoked the same toxic effects as free DXR. On the contrary, DXR-Np resulted more toxic since significant variations of both the body weight and the ECG parameters were observed during the first week of treatment. In addition, the rats treated with DXR-Np died between the 3(rd) and the 5(th) day after the 2(nd) administration. These results demonstrate that, in these experimental conditions, the couplage of DXR to nanoparticles enhanced the cardiotoxicity of the drug. Since DXR was linked to the protein matrix of nanoparticles via glutaraldehyde, the high toxicity of DXR-loaded nanoparticles could be due to the covalent binding of the drug to the carrier.
1997
52
385
388
General and cardiac toxicity of doxorubicin-loaded gelatin nanoparticles / Leo, Eliana Grazia; R., Arletti; Forni, Flavio; R., Cameroni. - In: IL FARMACO. - ISSN 0014-827X. - STAMPA. - 52:(1997), pp. 385-388.
Leo, Eliana Grazia; R., Arletti; Forni, Flavio; R., Cameroni
File in questo prodotto:
File Dimensione Formato  
1997 general and cardiac il farmaco.pdf

Accesso riservato

Tipologia: Versione pubblicata dall'editore
Dimensione 2.39 MB
Formato Adobe PDF
2.39 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/304636
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 25
  • ???jsp.display-item.citation.isi??? 22
social impact