This study surveyed 237 schoolchildren in a lead-polluted industriaI area in northern Italy to assess the relationship between various biological indicators (lead in blood, hair and teeth, and deltaaminolevulinic dehydratase [ALA-D] activity) and some neuropsychological functions, assessed by a battery of five psychometric tests. The geometric means of lead measured in blood, hair and teeth were 1O.99 ug/dl, 6.79 ug/g and 6.05 ug/g, respectively. Mean ALA-D activity was 5l mU/mi RBC. By analysis of covariance, after regressing out the variance accountable to confounding variables (age, sex, occupation/education of parents), Total and Verbal WISC-R IQ and Toulouse Pieron test results were significantly affected by the levels of lead in teeth. ALA-D values also appeared to be related to WISC-R IQ results (Total, Verbal and Performance).
Relationship between lead exposure indicators and neuropsychological performance in children / Bergomi, Margherita; Borella, Paola; Fantuzzi, Guglielmina; Vivoli, Gianfranco; Sturloni, Nicoletta; Cavazzuti, Giovanni Battista; Tampieri, Auro; Pl, Tartoni. - In: DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY. - ISSN 0012-1622. - STAMPA. - 31:(1989), pp. 181-190.
Relationship between lead exposure indicators and neuropsychological performance in children
BERGOMI, Margherita;BORELLA, Paola;FANTUZZI, Guglielmina;VIVOLI, Gianfranco;STURLONI, Nicoletta;CAVAZZUTI, Giovanni Battista;TAMPIERI, Auro;
1989
Abstract
This study surveyed 237 schoolchildren in a lead-polluted industriaI area in northern Italy to assess the relationship between various biological indicators (lead in blood, hair and teeth, and deltaaminolevulinic dehydratase [ALA-D] activity) and some neuropsychological functions, assessed by a battery of five psychometric tests. The geometric means of lead measured in blood, hair and teeth were 1O.99 ug/dl, 6.79 ug/g and 6.05 ug/g, respectively. Mean ALA-D activity was 5l mU/mi RBC. By analysis of covariance, after regressing out the variance accountable to confounding variables (age, sex, occupation/education of parents), Total and Verbal WISC-R IQ and Toulouse Pieron test results were significantly affected by the levels of lead in teeth. ALA-D values also appeared to be related to WISC-R IQ results (Total, Verbal and Performance).
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