By means of semiquantitative immunocytochemistry, possible age-related changes in dopamine and cyclic AMP-regulated phosphoprotein mr 32 (DARPP-32) and glial fibrillary acidic protein (GFAP) immunoreactivities (IR) were investigated in tanycytes of the arcuate nucleus. These two markers showed opposite changes during aging. DARPP-32 IR decreased by around 70%, whereas GFAP IR increased by around 300% in 24-month-old vs. 3-month-old rats. These changes were accompanied by a progressive loss in the number of tanycytes, measured by counting of their long processes in the arcuate nucleus. No significant age-related change was observed either in GFAP IR in astrocytic populations of the mediobasal hypothalamus or in tyrosine hydroxylase IR in dopaminergic neurons of the dorsal arcuate nucleus. These observations indicate that the tanycytic population of the arcuate nucleus undergoes important modifications during aging, which include cell loss, impairment in the intracellular signalling cascade linked to DARPP-32, and hypertrophy. These changes may be related to the alterations in the neuroendocrine systems known to occur during aging.

Age-related alterations in tanycytes of the mediobasal hypothalamus of the male rat / Zoli, Michele; F., Ferraguti; A., Frasoldati; Biagini, Giuseppe; Agnati, Luigi Francesco. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - STAMPA. - 16:(1995), pp. 77-83.

Age-related alterations in tanycytes of the mediobasal hypothalamus of the male rat

ZOLI, Michele;F. FERRAGUTI;BIAGINI, Giuseppe;AGNATI, Luigi Francesco
1995

Abstract

By means of semiquantitative immunocytochemistry, possible age-related changes in dopamine and cyclic AMP-regulated phosphoprotein mr 32 (DARPP-32) and glial fibrillary acidic protein (GFAP) immunoreactivities (IR) were investigated in tanycytes of the arcuate nucleus. These two markers showed opposite changes during aging. DARPP-32 IR decreased by around 70%, whereas GFAP IR increased by around 300% in 24-month-old vs. 3-month-old rats. These changes were accompanied by a progressive loss in the number of tanycytes, measured by counting of their long processes in the arcuate nucleus. No significant age-related change was observed either in GFAP IR in astrocytic populations of the mediobasal hypothalamus or in tyrosine hydroxylase IR in dopaminergic neurons of the dorsal arcuate nucleus. These observations indicate that the tanycytic population of the arcuate nucleus undergoes important modifications during aging, which include cell loss, impairment in the intracellular signalling cascade linked to DARPP-32, and hypertrophy. These changes may be related to the alterations in the neuroendocrine systems known to occur during aging.
1995
16
77
83
Age-related alterations in tanycytes of the mediobasal hypothalamus of the male rat / Zoli, Michele; F., Ferraguti; A., Frasoldati; Biagini, Giuseppe; Agnati, Luigi Francesco. - In: NEUROBIOLOGY OF AGING. - ISSN 0197-4580. - STAMPA. - 16:(1995), pp. 77-83.
Zoli, Michele; F., Ferraguti; A., Frasoldati; Biagini, Giuseppe; Agnati, Luigi Francesco
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/304506
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