Microparticles with size less than 3 mum, able to be taken up by M cell of Peyer's patches for the drug delivery to the Gut Associated Limphoid Tissue (GALT). were developed in order to improve oral bioavailability of Polymyxin B (PMB). Less than 3 mum alginate microparticles resistant to gastro-intestinal media were prepared by. spray-drying technique and cross-linking by calcium ions and chitosan. The cross-linked microparticles,were evaluated for PMB content by spectrophotometric method, alginate/PMB interaction by rheological study. cross-linking degree by EDS analysis and PMB activity by microbiological assay. By modulating the polymer cross-linking degree, cationic PMB interacted on alginate chains leading to a proper PMB loading as well as antibiotic retention in gastric environment and sustained delivery in intestinal fluid. Moreover, the procedure resulted suitable for PMB biological activity preservation.

Alginate microparticles for Polymyxin B Peyer's patches uptake: microparticles for antibiotic oral administration / Coppi, Gilberto; Iannuccelli, Valentina; N., Sala; Bondi, Moreno. - In: JOURNAL OF MICROENCAPSULATION. - ISSN 0265-2048. - STAMPA. - 21:(2004), pp. 829-839. [10.1080/02652040400015437]

Alginate microparticles for Polymyxin B Peyer's patches uptake: microparticles for antibiotic oral administration

COPPI, Gilberto;IANNUCCELLI, Valentina;BONDI, Moreno
2004

Abstract

Microparticles with size less than 3 mum, able to be taken up by M cell of Peyer's patches for the drug delivery to the Gut Associated Limphoid Tissue (GALT). were developed in order to improve oral bioavailability of Polymyxin B (PMB). Less than 3 mum alginate microparticles resistant to gastro-intestinal media were prepared by. spray-drying technique and cross-linking by calcium ions and chitosan. The cross-linked microparticles,were evaluated for PMB content by spectrophotometric method, alginate/PMB interaction by rheological study. cross-linking degree by EDS analysis and PMB activity by microbiological assay. By modulating the polymer cross-linking degree, cationic PMB interacted on alginate chains leading to a proper PMB loading as well as antibiotic retention in gastric environment and sustained delivery in intestinal fluid. Moreover, the procedure resulted suitable for PMB biological activity preservation.
2004
21
829
839
Alginate microparticles for Polymyxin B Peyer's patches uptake: microparticles for antibiotic oral administration / Coppi, Gilberto; Iannuccelli, Valentina; N., Sala; Bondi, Moreno. - In: JOURNAL OF MICROENCAPSULATION. - ISSN 0265-2048. - STAMPA. - 21:(2004), pp. 829-839. [10.1080/02652040400015437]
Coppi, Gilberto; Iannuccelli, Valentina; N., Sala; Bondi, Moreno
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/304388
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