The behavioural effects induced in male Wistar rats by SND 919, a new drug reputed to have selective agonistic activity at D-2 dopamine (DA) receptors, were studied. The following aspects of behaviour were considered: motor activity, stretching-yawning (SY), penile erection (PE) and stereotyped behaviour (SB). Intraperitoneal injection (IP) of the drug (0.01-20 mg/kg) induced an SY syndrome in the form of a bell-shaped dose-response curve, the effect being maximal at the dose of 0.1 mg/kg and disappearing completely at 10 mg/kg. SND 919 also potently elicited PE; this latter effect, however, was not coincident with SY induction, being maximal at 1 mg/kg and persisting at 10 and 20 mg/kg. SND 919-induced SY was potently antagonized by pretreatment not only with the D-2 antagonist, L-sulpiride (20 mg/kg), but also with the alpha(2) antagonist, yohimbine (1, 3 mg/kg), and the more selective alpha(2) antagonist, idazoxan (1, 2 and 5 mg/kg). While sulpiride also decreased SND 919-induced PE, idazoxan at all doses and yohimbine at 1 mg/kg did not affect this behaviour. Inhibition of motor activity was induced by the D-2 agonist at low doses (0.05, 0.1 mg/kg), while at high doses (1, 10 and 20 mg/kg), it was actually replaced by a form of SB characterized by downward sniffing and licking. When, for comparison, the D-2 agonist, RU 24213 (0.1-20 mg/kg IF), was tested for PE, SY, motor activity and SB, it displayed a behavioural pattern very similar to that obtained with SND 919. Idazoxan (2 mg/kg), administered before RU 24213 (10 mg/kg), significantly antagonized the drug-induced SY, but not PE. The discussion centres on the specific neurochemical mechanisms presumably underlying the various forms of SND 919-induced behaviour and, in particular, PE and SY, which seem to differ, at least with respect to alpha(2) involvement.

BEHAVIORAL EVIDENCE THAT DIFFERENT NEUROCHEMICAL MECHANISMS UNDERLY STRETCHING-YAWNING AND PENILE ERECTION INDUCED IN MALE-RATS BY SND-919, A NEW SELECTIVE D-2 DOPAMINE-RECEPTOR AGONIST / F., Ferrari; F., Pelloni; Giuliani, Daniela. - In: PSYCHOPHARMACOLOGY. - ISSN 0033-3158. - STAMPA. - 113:(1993), pp. 172-176.

BEHAVIORAL EVIDENCE THAT DIFFERENT NEUROCHEMICAL MECHANISMS UNDERLY STRETCHING-YAWNING AND PENILE ERECTION INDUCED IN MALE-RATS BY SND-919, A NEW SELECTIVE D-2 DOPAMINE-RECEPTOR AGONIST

GIULIANI, Daniela
1993

Abstract

The behavioural effects induced in male Wistar rats by SND 919, a new drug reputed to have selective agonistic activity at D-2 dopamine (DA) receptors, were studied. The following aspects of behaviour were considered: motor activity, stretching-yawning (SY), penile erection (PE) and stereotyped behaviour (SB). Intraperitoneal injection (IP) of the drug (0.01-20 mg/kg) induced an SY syndrome in the form of a bell-shaped dose-response curve, the effect being maximal at the dose of 0.1 mg/kg and disappearing completely at 10 mg/kg. SND 919 also potently elicited PE; this latter effect, however, was not coincident with SY induction, being maximal at 1 mg/kg and persisting at 10 and 20 mg/kg. SND 919-induced SY was potently antagonized by pretreatment not only with the D-2 antagonist, L-sulpiride (20 mg/kg), but also with the alpha(2) antagonist, yohimbine (1, 3 mg/kg), and the more selective alpha(2) antagonist, idazoxan (1, 2 and 5 mg/kg). While sulpiride also decreased SND 919-induced PE, idazoxan at all doses and yohimbine at 1 mg/kg did not affect this behaviour. Inhibition of motor activity was induced by the D-2 agonist at low doses (0.05, 0.1 mg/kg), while at high doses (1, 10 and 20 mg/kg), it was actually replaced by a form of SB characterized by downward sniffing and licking. When, for comparison, the D-2 agonist, RU 24213 (0.1-20 mg/kg IF), was tested for PE, SY, motor activity and SB, it displayed a behavioural pattern very similar to that obtained with SND 919. Idazoxan (2 mg/kg), administered before RU 24213 (10 mg/kg), significantly antagonized the drug-induced SY, but not PE. The discussion centres on the specific neurochemical mechanisms presumably underlying the various forms of SND 919-induced behaviour and, in particular, PE and SY, which seem to differ, at least with respect to alpha(2) involvement.
1993
113
172
176
BEHAVIORAL EVIDENCE THAT DIFFERENT NEUROCHEMICAL MECHANISMS UNDERLY STRETCHING-YAWNING AND PENILE ERECTION INDUCED IN MALE-RATS BY SND-919, A NEW SELECTIVE D-2 DOPAMINE-RECEPTOR AGONIST / F., Ferrari; F., Pelloni; Giuliani, Daniela. - In: PSYCHOPHARMACOLOGY. - ISSN 0033-3158. - STAMPA. - 113:(1993), pp. 172-176.
F., Ferrari; F., Pelloni; Giuliani, Daniela
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