We evaluated neuropeptide Y (NPY) and galanin (GAL) immunoreactivity (IR) and mRNA in the paraventricular and arcuate nucleus, respectively, in rats that became overweight (Ov) or not (NOv) when fed a cafeteria diet. After 2 months of diet, NOv rats showed a significant increase in NPY IR, whereas Ov rats showed a significant increase in GAL mRNA levels. None of these changes was present in rats overfed for 6.5 months. These differential changes in hypothalamic GAL and NPY transmissions may contribute to the different susceptibility of the two rat subpopulations to the weight-promoting effects of the hypercaloric diet.
Hypothalamic neuropeptide Y and galanin in overweight rats fed a cafeteria diet / Pedrazzi, Patrizia; L., Cattaneo; L., Valeriani; S., Boschi; D., Cocchi; Zoli, Michele. - In: PEPTIDES. - ISSN 0196-9781. - STAMPA. - 19:(1998), pp. 157-165.
Hypothalamic neuropeptide Y and galanin in overweight rats fed a cafeteria diet
PEDRAZZI, Patrizia;ZOLI, Michele
1998
Abstract
We evaluated neuropeptide Y (NPY) and galanin (GAL) immunoreactivity (IR) and mRNA in the paraventricular and arcuate nucleus, respectively, in rats that became overweight (Ov) or not (NOv) when fed a cafeteria diet. After 2 months of diet, NOv rats showed a significant increase in NPY IR, whereas Ov rats showed a significant increase in GAL mRNA levels. None of these changes was present in rats overfed for 6.5 months. These differential changes in hypothalamic GAL and NPY transmissions may contribute to the different susceptibility of the two rat subpopulations to the weight-promoting effects of the hypercaloric diet.
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