The feasibility of different techniques for the preparation of tolmetin-loaded microparticles of Eudragit RL100 and Eudragit RS100 was evaluated. The traditional emulsion-solvent evaporation method was compared to spray-drying and the quasi-emulsion-solvent diffusion technique. The results were analysed in terms of drug encapsulation and in vitro release (pH 1.2 and 6.8), as well as in terms of particle yield and size distribution. Preliminary physicochemical studies also indicated the possibility of a polymorphic change of the drug during the microsphere preparation using the first procedure.
Properties of tolmetin-loaded Eudragit RL100 and Eudragit RS100 microparticles prepared by different techniques / R., Pignatello; Vandelli, Maria Angela; P., Giunchedi; G., Puglisi. - In: STP PHARMA SCIENCES. - ISSN 1157-1489. - STAMPA. - 7:(1997), pp. 148-157.
Properties of tolmetin-loaded Eudragit RL100 and Eudragit RS100 microparticles prepared by different techniques
VANDELLI, Maria Angela;
1997
Abstract
The feasibility of different techniques for the preparation of tolmetin-loaded microparticles of Eudragit RL100 and Eudragit RS100 was evaluated. The traditional emulsion-solvent evaporation method was compared to spray-drying and the quasi-emulsion-solvent diffusion technique. The results were analysed in terms of drug encapsulation and in vitro release (pH 1.2 and 6.8), as well as in terms of particle yield and size distribution. Preliminary physicochemical studies also indicated the possibility of a polymorphic change of the drug during the microsphere preparation using the first procedure.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
