The interaction of chenodeoxycholic acid (3 alpha,7 alpha-dihydroxy-5 beta-cholan-24-oic acid) 1; cholic acid (3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholan-24-oic acid) 2, deoxycholic acid (3 alpha,12 alpha-dihydroxy-5 beta-cholan-24-oic acid) 3 and ursodeoxycholic acid (3 alpha,7 beta-dihydroxy-5 beta-cholan-24-oic acid) 4 with 2-hydroxypropyl-beta-cyclodextrin HP beta CD (partially functionalized) is studied by measuring the changes in C-13-NMR chemical shifts induced by complexation in methanol-d(4). The alkyl chain of the bile acids enters the cyclodextrin cavity. The interaction of 1 and 4 with HP beta CD is stronger, in this solvent, with respect that of 2 and 3.

Complexation of bile acids with 2-hydroxypropyl-beta-cyclodextrin: A C-13-NMR study / Mucci, Adele; Vandelli, Maria Angela; Salvioli, Gianfranco; L., Malmusi; Forni, Flavio; Schenetti, Luisa. - In: SUPRAMOLECULAR CHEMISTRY. - ISSN 1061-0278. - STAMPA. - 7:(1996), pp. 125-127.

Complexation of bile acids with 2-hydroxypropyl-beta-cyclodextrin: A C-13-NMR study

MUCCI, Adele;VANDELLI, Maria Angela;SALVIOLI, Gianfranco;FORNI, Flavio;SCHENETTI, Luisa
1996

Abstract

The interaction of chenodeoxycholic acid (3 alpha,7 alpha-dihydroxy-5 beta-cholan-24-oic acid) 1; cholic acid (3 alpha,7 alpha,12 alpha-trihydroxy-5 beta-cholan-24-oic acid) 2, deoxycholic acid (3 alpha,12 alpha-dihydroxy-5 beta-cholan-24-oic acid) 3 and ursodeoxycholic acid (3 alpha,7 beta-dihydroxy-5 beta-cholan-24-oic acid) 4 with 2-hydroxypropyl-beta-cyclodextrin HP beta CD (partially functionalized) is studied by measuring the changes in C-13-NMR chemical shifts induced by complexation in methanol-d(4). The alkyl chain of the bile acids enters the cyclodextrin cavity. The interaction of 1 and 4 with HP beta CD is stronger, in this solvent, with respect that of 2 and 3.
7
125
127
Complexation of bile acids with 2-hydroxypropyl-beta-cyclodextrin: A C-13-NMR study / Mucci, Adele; Vandelli, Maria Angela; Salvioli, Gianfranco; L., Malmusi; Forni, Flavio; Schenetti, Luisa. - In: SUPRAMOLECULAR CHEMISTRY. - ISSN 1061-0278. - STAMPA. - 7:(1996), pp. 125-127.
Mucci, Adele; Vandelli, Maria Angela; Salvioli, Gianfranco; L., Malmusi; Forni, Flavio; Schenetti, Luisa
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/304122
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