Inserting genetic information at precise locations into the human genome has been the goal of the gene therapy community for almost two decades. Despite their spectacular progress in many fields of mammalian genetics, genome editing and homologous recombination are still too inefficient to be applied to human primary cells and tissues, the targets of any medical application. Site-specific integration, or the insertion of genes at known locations by enzymes that target recognition capacity, has progressed slowly but steadily in recent years, and could very well be the basis of the next generation of gene transfer technology.

Site-specific integration into the human genome: Ready for clinical application? / Recchia, Alessandra; Mavilio, Fulvio. - In: REJUVENATION RESEARCH. - ISSN 1549-1684. - STAMPA. - 9:(2006), pp. 446-449.

Site-specific integration into the human genome: Ready for clinical application?

RECCHIA, Alessandra;MAVILIO, Fulvio
2006

Abstract

Inserting genetic information at precise locations into the human genome has been the goal of the gene therapy community for almost two decades. Despite their spectacular progress in many fields of mammalian genetics, genome editing and homologous recombination are still too inefficient to be applied to human primary cells and tissues, the targets of any medical application. Site-specific integration, or the insertion of genes at known locations by enzymes that target recognition capacity, has progressed slowly but steadily in recent years, and could very well be the basis of the next generation of gene transfer technology.
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Site-specific integration into the human genome: Ready for clinical application? / Recchia, Alessandra; Mavilio, Fulvio. - In: REJUVENATION RESEARCH. - ISSN 1549-1684. - STAMPA. - 9:(2006), pp. 446-449.
Recchia, Alessandra; Mavilio, Fulvio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/304047
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