The interactions between neuropeptide Y (NPY), specifically through NPY Y-1 and Y-2 receptor subtypes, and galanin [GAL(1-29)] have been analysed at the cardiovascular level. The cardiovascular effects of intracisternal coinjections of GAL(1-29) with NPY or NPY Y-1 or Y-2 agonists, as well as quantitative receptor autoradiography of the binding characteristics of NPY Y-1 and Y-2 receptor subtypes in the nucleus of the solitary tract (NTS), in the presence or absence of GAL(1-29), have been investigated. The effects of coinjections of GAL(1-29) and the NPY Y-1 agonist on the expression of c-FOS immunoreactivity in the NTS were also studied. The coinjection of NPY with GAL(1-29) induced a significant vasopressor and tachycardic action with a maximum 40% increase (P < 0.001). The coinjection of the NPY Y-1 agonist and GAL(1-29) induced a similar increase in mean arterial pressure and heart rate as did NPY plus GAL(1-29), actions that were not observed with the NPY Y-2 agonist plus GAL (1-29).GAL (1-29), 3 nm, significantly and substantially (by similar to 40%) decreased NPY Y-1 agonist binding in the NTS. This effect was significantly blocked (P < 0.01) in the presence of the specific galanin antagonist M35. The NPY Y-2 agonist binding was not modified in the presence of GAL(1-29). At the c-FOS level, the coinjection of NPY Y-1 and GAL(1-29) significantly reduced the c-FOS-immunoreactive response induced by either of the two peptides. The present findings suggest the existence of a modulatory antagonistic effect of GAL(1-29) mediated via galanin receptors on the NPY Y-1 receptor subtype and its signalling within the NTS.
|Anno di pubblicazione:||2006|
|Titolo:||Galanin-neuropeptide Y (NPY) interactions in central cardiovascular control: involvement of the NPYY1 receptor subtype|
|Autore/i:||Z. Diaz-Cabiale; C. Parrado; A. Rivera; A. de la Calle; L. Agnati; K. Fuxe; JA Narvaez|
|Codice identificativo ISI:||WOS:000239152900017|
|Codice identificativo Scopus:||2-s2.0-33746215799|
|Citazione:||Galanin-neuropeptide Y (NPY) interactions in central cardiovascular control: involvement of the NPYY1 receptor subtype / Z. Diaz-Cabiale; C. Parrado; A. Rivera; A. de la Calle; L. Agnati; K. Fuxe; JA Narvaez. - In: EUROPEAN JOURNAL OF NEUROSCIENCE. - ISSN 0953-816X. - STAMPA. - 24(2006), pp. 499-508.|
|Tipologia||Articolo su rivista|
File in questo prodotto:
I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris