Calbindin D-28K is a neuronal calcium binding protein which may act as a buffer of neuronal calcium. Evidence suggests that disturbance of calcium homeostasis is important in neurodegeneration, possibly via changes in calbindin D-28K. Immunoreactivity of calbindin D-28K is compared in Alzheimer's disease and age-matched controls. The size and number of calbindin D-28K positive neurons in Alzheimer's disease tissue is reduced. There is also shrinkage of the dendritic tree. Continuing work examines the function of calbindin D-28K using transgenic mice.
Calcium homeostasis in ageing: studies on the calcium binding protein calbindin D-28K / G., Lally; Rl, Faull; Hj, Waldvogel; Ferrari, Stefano; Pc, Emson. - In: JOURNAL OF NEURAL TRANSMISSION. - ISSN 0300-9564. - 104:(1997), pp. 1107-1112. [10.1007/BF01273323]
Calcium homeostasis in ageing: studies on the calcium binding protein calbindin D-28K
FERRARI, Stefano;
1997
Abstract
Calbindin D-28K is a neuronal calcium binding protein which may act as a buffer of neuronal calcium. Evidence suggests that disturbance of calcium homeostasis is important in neurodegeneration, possibly via changes in calbindin D-28K. Immunoreactivity of calbindin D-28K is compared in Alzheimer's disease and age-matched controls. The size and number of calbindin D-28K positive neurons in Alzheimer's disease tissue is reduced. There is also shrinkage of the dendritic tree. Continuing work examines the function of calbindin D-28K using transgenic mice.
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