As the pore morphology influences drug release, the purpose is to study pore characteristics by comparing bead performances. Casein/gelatin beads have been prepared by the emulsification extraction method, cross-linked with D,L-glyceraldehyde in acetone:water mixture 3:1 (v/v) and loaded with sodium fluorescein as a model drug. The beads with higher casein percentage have a higher matrix porosity, a wider average pore diameter and a higher cross-linking degree. The higher casein percentage causes a lower drug release rate. The kinetic analysis shows that the drug release occurs bq diffusion and that the diffusion coefficient is affected by the casein percentage and the cross-linking degree. It can be hypothesized that the pore and channel morphology (tortuosity.), due to the casein percentage in the matrix and the cross-linking treatment, can he evaluated by kinetic analysis of the release data.
Can kinetic analysis be a tool for evaluating pore characteristics? / E., Bulgarelli; Forni, Flavio; Mt, Bernabei. - In: JOURNAL OF MICROENCAPSULATION. - ISSN 0265-2048. - STAMPA. - 17:6(2000), pp. 701-710. [10.1080/02652040050161693]