IL-6 is a pleiotropic pro-inflammatory cytokine thought to play a role in age physiology, even if its possible modulation by aging mechanisms has not been fully defined. In this paper, the morpho-functional modifications and IL-6 immunoreactivity during, aging in a simple invertebrate model, Ophryotrocha labronica, are reported. The comparison between newly-hatched, juveniles, young adult and 3-month-old females showed significant differences in the nervous and genital systems. There is evidence of nerve cell loss and a decline in oocyte growth and maturation at the gonad level. Immunohistochemistry reveals a different distribution of IL-6-like molecules, and a decreased number of reactive nerve cells in the central nervous system of aged O. labronica associated to the induced morphological modifications. (c) 2006 Elsevier Ltd. All rights reserved.

IL-6 immunoreactivity changes during aging in the polychaete Ophryotrocha labronica (Polychaeta: Dorvilleidae) / Franchini, Antonella; Ottaviani, Enzo. - In: TISSUE & CELL. - ISSN 0040-8166. - STAMPA. - 39:(2007), pp. 27-34.

IL-6 immunoreactivity changes during aging in the polychaete Ophryotrocha labronica (Polychaeta: Dorvilleidae)

FRANCHINI, Antonella;OTTAVIANI, Enzo
2007-01-01

Abstract

IL-6 is a pleiotropic pro-inflammatory cytokine thought to play a role in age physiology, even if its possible modulation by aging mechanisms has not been fully defined. In this paper, the morpho-functional modifications and IL-6 immunoreactivity during, aging in a simple invertebrate model, Ophryotrocha labronica, are reported. The comparison between newly-hatched, juveniles, young adult and 3-month-old females showed significant differences in the nervous and genital systems. There is evidence of nerve cell loss and a decline in oocyte growth and maturation at the gonad level. Immunohistochemistry reveals a different distribution of IL-6-like molecules, and a decreased number of reactive nerve cells in the central nervous system of aged O. labronica associated to the induced morphological modifications. (c) 2006 Elsevier Ltd. All rights reserved.
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IL-6 immunoreactivity changes during aging in the polychaete Ophryotrocha labronica (Polychaeta: Dorvilleidae) / Franchini, Antonella; Ottaviani, Enzo. - In: TISSUE & CELL. - ISSN 0040-8166. - STAMPA. - 39:(2007), pp. 27-34.
Franchini, Antonella; Ottaviani, Enzo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/303850
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