The influence of putrescine on cardiac arrhythmias induced by either permanent ligature of the left anterior coronary artery or heart reperfusion following a 5-min coronary occlusion was studied in anesthetized rats. Reperfusion-induced arrhythmias were significantly prevented by the i.v. injection of 150-200 mg/kg of putrescine, the survival rate being 100% in treated animals and 40% in controls. At a dose level of 200-300 mg/kg i.v., putrescine also significantly reduced the duration of ventricular tachicardia induced by permanent coronary occlusion. These findings show that putrescine significantly reduces the consequences of cardiac ischemia and reperfusion, probably as a consequence of its multiple stabilizing effects at the membrane level.

Ischemia-induced and reperfusion-induced arrhythmias are prevented by putrescine / S., Tagliavini; Genedani, Susanna; Bertolini, Alfio; Bazzani, Carla. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 194:(1991), pp. 7-10.

Ischemia-induced and reperfusion-induced arrhythmias are prevented by putrescine

GENEDANI, Susanna;BERTOLINI, Alfio;BAZZANI, Carla
1991

Abstract

The influence of putrescine on cardiac arrhythmias induced by either permanent ligature of the left anterior coronary artery or heart reperfusion following a 5-min coronary occlusion was studied in anesthetized rats. Reperfusion-induced arrhythmias were significantly prevented by the i.v. injection of 150-200 mg/kg of putrescine, the survival rate being 100% in treated animals and 40% in controls. At a dose level of 200-300 mg/kg i.v., putrescine also significantly reduced the duration of ventricular tachicardia induced by permanent coronary occlusion. These findings show that putrescine significantly reduces the consequences of cardiac ischemia and reperfusion, probably as a consequence of its multiple stabilizing effects at the membrane level.
1991
194
7
10
Ischemia-induced and reperfusion-induced arrhythmias are prevented by putrescine / S., Tagliavini; Genedani, Susanna; Bertolini, Alfio; Bazzani, Carla. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - STAMPA. - 194:(1991), pp. 7-10.
S., Tagliavini; Genedani, Susanna; Bertolini, Alfio; Bazzani, Carla
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/303518
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