Chemotherapy, as generally available, is of a limited value in curing malignant brain tumors (gliomas), which often develop resistance to drugs, becoming completely unresponsive to any standard therapeutic approach. Camptothecins, a family of topoisomerase I inhibitor drugs, represent a new promising treatment strategy and are currently under evaluation for testing the clinical efficacy. We selected a CPT-resistant sub-line (U87CPT-R) from U87-MG grade III-IV astrocytoma cells, and compared the expression profile of the two cell lines by cDNA-microarray, as a preliminary screening of the molecular mechanisms involved in the acquisition of CPT resistance in glioma cells. The relevant role of IL-1 beta overproduction as well as a generalised up-regulation of genes implicated in angiogenesis and inflammatory response are discussed in details.
Anno di pubblicazione: | 2006 |
Titolo: | A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines |
Autore/i: | Morandi E; Zingaretti C; Chiozzotto D; Severini C; Semeria A; Horn W; Vaccari M; Serra R; Silingardi P; Colacci A |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 231 |
Pagina iniziale: | 74 |
Pagina finale: | 86 |
Codice identificativo ISI: | WOS:000234622600009 |
Codice identificativo Scopus: | 2-s2.0-28844454649 |
Citazione: | A cDNA-microarray analysis of camptothecin resistance in glioblastoma cell lines / Morandi E; Zingaretti C; Chiozzotto D; Severini C; Semeria A; Horn W; Vaccari M; Serra R; Silingardi P; Colacci A. - In: CANCER LETTERS. - ISSN 0304-3835. - STAMPA. - 231(2006), pp. 74-86. |
Tipologia | Articolo su rivista |
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