The triphenyl phosphite-chlorine reagent, freshly in situ prepared by the action of chlorine on a solution of triphenyl phosphite in dichloromethane, is successfully used in the cleavage of both sulfonamides and sulfonamides under extremely mild conditions (-15 degrees C to r.t.). Final amines are easily recovered by a simple acid/base extraction, and no further purification is required.
Applications of the (PhO)(3)PCl2 reagent: A new protocol for mild cleavage of sulfinamides and sulfonamides / Spaggiari, Alberto; Prati, Fabio. - In: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS. - ISSN 1042-6507. - STAMPA. - 181:8(2006), pp. 1825-1830. [10.1080/10426500500542927]
Applications of the (PhO)(3)PCl2 reagent: A new protocol for mild cleavage of sulfinamides and sulfonamides
SPAGGIARI, Alberto;PRATI, Fabio
2006
Abstract
The triphenyl phosphite-chlorine reagent, freshly in situ prepared by the action of chlorine on a solution of triphenyl phosphite in dichloromethane, is successfully used in the cleavage of both sulfonamides and sulfonamides under extremely mild conditions (-15 degrees C to r.t.). Final amines are easily recovered by a simple acid/base extraction, and no further purification is required.
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