C/EBP alpha and C/EBP beta, two transcription factors of the C/EBP family play important roles in the proliferation and differentiation of various cell types including myeloid progenitors. Expression of C/EBP alpha and C/EBP beta is repressed in myeloid blast crisis of Chronic Myelogenous Leukemia by mechanisms that involve translation repression which depends on the interaction of RNA-binding proteins with conserved binding sites in the 5'UTR of c/ebp alpha and c/ebp beta mRNA. Ectopic expression of C/EBP alpha and C/EBP beta in myeloid progenitors expressing the BCR/ABL oncogene inhibits proliferation, induces differentiation and suppresses leukemogenesis in mice, but C/EBP a is markedly more effective than C/EBP beta. The more potent effects of C/EBP a probably depends on protein-protein interaction with cell-cycle regulatory proteins, but the pattern of genes modulated by C/EBP alpha and C/EBP beta is not completely overlapping. This suggests that transcription-dependent and -independent effects are both involved and support the therapeutic potential of reactivating C/EBP alpha and C/EBP beta expression in leukemic cells.

Effects of C/EBP alpha and C/EBP beta in BCR/ABL-expressing cells - Differences and similarities / Guerzoni, Clara; Ferrari, Giovanna; Bardini, M; Mariani, Sa; Calabretta, Bruno. - In: CELL CYCLE. - ISSN 1538-4101. - STAMPA. - 5:12(2006), pp. 1254-1257. [10.4161/cc.5.12.2808]

Effects of C/EBP alpha and C/EBP beta in BCR/ABL-expressing cells - Differences and similarities

GUERZONI, Clara;FERRARI, Giovanna;CALABRETTA, Bruno
2006

Abstract

C/EBP alpha and C/EBP beta, two transcription factors of the C/EBP family play important roles in the proliferation and differentiation of various cell types including myeloid progenitors. Expression of C/EBP alpha and C/EBP beta is repressed in myeloid blast crisis of Chronic Myelogenous Leukemia by mechanisms that involve translation repression which depends on the interaction of RNA-binding proteins with conserved binding sites in the 5'UTR of c/ebp alpha and c/ebp beta mRNA. Ectopic expression of C/EBP alpha and C/EBP beta in myeloid progenitors expressing the BCR/ABL oncogene inhibits proliferation, induces differentiation and suppresses leukemogenesis in mice, but C/EBP a is markedly more effective than C/EBP beta. The more potent effects of C/EBP a probably depends on protein-protein interaction with cell-cycle regulatory proteins, but the pattern of genes modulated by C/EBP alpha and C/EBP beta is not completely overlapping. This suggests that transcription-dependent and -independent effects are both involved and support the therapeutic potential of reactivating C/EBP alpha and C/EBP beta expression in leukemic cells.
2006
5
12
1254
1257
Effects of C/EBP alpha and C/EBP beta in BCR/ABL-expressing cells - Differences and similarities / Guerzoni, Clara; Ferrari, Giovanna; Bardini, M; Mariani, Sa; Calabretta, Bruno. - In: CELL CYCLE. - ISSN 1538-4101. - STAMPA. - 5:12(2006), pp. 1254-1257. [10.4161/cc.5.12.2808]
Guerzoni, Clara; Ferrari, Giovanna; Bardini, M; Mariani, Sa; Calabretta, Bruno
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/2635
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