Hemophagocytic syndrome (HS) may occur as a consequence of herpes viral infections. Human herpesvirus 8 (HHV-8)/Kaposi sarcoma-associated herpesvirus has so far been recognized as a trigger of HS only in immunosuppressed subjects or in patients with Kaposi sarcoma and/or HHV-8-related lymphoproliferative diseases. We report two Italian human immunodeficiency virus (HIV)-negative elderly men who developed an HS with a rapidly fatal course, following treatment with corticosteroids for autoimmune hemolytic anemia. An overwhelming active infection with HHV-8 was unequivocally documented by molecular and immunohistochemical methods, in the absence of HHV-8-related tumors. The occurrence of HHV-8-associated HS, although rare, may be considered, even out of the HIV or the transplantation settings, at least in areas endemic for HHV-8 infection.

Fatal hemophagocytic syndrome related to active human herpesvirus-8/Kaposi sarcoma-associated herpesvirus infection in human immunodeficiency virus-negative, non-transplant patients without related malignancies / Re, A; Facchetti, F; Borlenghi, E; Cattaneo, C; Capucci, Ma; Ungari, M; Barozzi, Patrizia; Vallerini, Daniela; Potenza, Leonardo; Torelli, Giuseppe; Rossi, G; Luppi, Mario. - In: EUROPEAN JOURNAL OF HAEMATOLOGY. - ISSN 0902-4441. - STAMPA. - 78:4(2007), pp. 361-364. [10.1111/j.1600-0609.2007.00828.x]

Fatal hemophagocytic syndrome related to active human herpesvirus-8/Kaposi sarcoma-associated herpesvirus infection in human immunodeficiency virus-negative, non-transplant patients without related malignancies

BAROZZI, Patrizia;VALLERINI, Daniela;POTENZA, Leonardo;TORELLI, Giuseppe;LUPPI, Mario
2007

Abstract

Hemophagocytic syndrome (HS) may occur as a consequence of herpes viral infections. Human herpesvirus 8 (HHV-8)/Kaposi sarcoma-associated herpesvirus has so far been recognized as a trigger of HS only in immunosuppressed subjects or in patients with Kaposi sarcoma and/or HHV-8-related lymphoproliferative diseases. We report two Italian human immunodeficiency virus (HIV)-negative elderly men who developed an HS with a rapidly fatal course, following treatment with corticosteroids for autoimmune hemolytic anemia. An overwhelming active infection with HHV-8 was unequivocally documented by molecular and immunohistochemical methods, in the absence of HHV-8-related tumors. The occurrence of HHV-8-associated HS, although rare, may be considered, even out of the HIV or the transplantation settings, at least in areas endemic for HHV-8 infection.
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364
Fatal hemophagocytic syndrome related to active human herpesvirus-8/Kaposi sarcoma-associated herpesvirus infection in human immunodeficiency virus-negative, non-transplant patients without related malignancies / Re, A; Facchetti, F; Borlenghi, E; Cattaneo, C; Capucci, Ma; Ungari, M; Barozzi, Patrizia; Vallerini, Daniela; Potenza, Leonardo; Torelli, Giuseppe; Rossi, G; Luppi, Mario. - In: EUROPEAN JOURNAL OF HAEMATOLOGY. - ISSN 0902-4441. - STAMPA. - 78:4(2007), pp. 361-364. [10.1111/j.1600-0609.2007.00828.x]
Re, A; Facchetti, F; Borlenghi, E; Cattaneo, C; Capucci, Ma; Ungari, M; Barozzi, Patrizia; Vallerini, Daniela; Potenza, Leonardo; Torelli, Giuseppe; Rossi, G; Luppi, Mario
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/23154
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