The growth rate of a tumor cell population depends on two major factors: the percentage of proliferating cells (cell growth fraction) and the rapidity of their duplication (cell proliferation rate). The authors evaluated the prognostic and predictive value of both kinetics parameters in a large series of breast cancer patients (n = 504). The cell growth fraction was determined by MIB-1 immunostaining, the cell proliferation rate by AgNOR analysis. Ki-67 LI (labeling index) and AgNOR area were significantly associated with histotype, histologic grade, tumor size, estrogen/progesterone receptor status, patient age, and lymph node involvement (P < 0.005). In the entire series of patients, both kinetics variables were significantly and independently associated with the clinical outcome, but their prognostic relevance was quite different when node-negative and node-positive patients were considered separately. Although in node-positive patients Ki-67 LI and AgNOR area were the unique independent predictors of disease-free and overall survival, they were excluded by the multivariate Cox model in node-negative patients, where only tumor size and estrogen receptor status retained a significant P-value. These results show that in breast carcinoma the cell growth fraction and the cell proliferation rate have a different prognostic impact with respect to the lymph node status and are major determinants of clinical outcome in node-positive patients only. Within this subgroup, the rapidity of cell proliferation as assessed by AgNOR analysis also served as a sensitive predictor of the response to adjuvant treatments.

Cell proliferation in breast cancer is a major determinant of clinical outcome in node-positive but not in node-negative patients / Trere, D; Ceccarelli, C; Migaldi, Mario; Santini, D; Taffurelli, M; Tosti, E; Chieco, P; Derenzini, M.. - In: APPLIED IMMUNOHISTOCHEMISTRY AND MOLECULAR MORPHOLOGY. - ISSN 1541-2016. - STAMPA. - 14:(2006), pp. 314-323.

Cell proliferation in breast cancer is a major determinant of clinical outcome in node-positive but not in node-negative patients

MIGALDI, Mario;
2006

Abstract

The growth rate of a tumor cell population depends on two major factors: the percentage of proliferating cells (cell growth fraction) and the rapidity of their duplication (cell proliferation rate). The authors evaluated the prognostic and predictive value of both kinetics parameters in a large series of breast cancer patients (n = 504). The cell growth fraction was determined by MIB-1 immunostaining, the cell proliferation rate by AgNOR analysis. Ki-67 LI (labeling index) and AgNOR area were significantly associated with histotype, histologic grade, tumor size, estrogen/progesterone receptor status, patient age, and lymph node involvement (P < 0.005). In the entire series of patients, both kinetics variables were significantly and independently associated with the clinical outcome, but their prognostic relevance was quite different when node-negative and node-positive patients were considered separately. Although in node-positive patients Ki-67 LI and AgNOR area were the unique independent predictors of disease-free and overall survival, they were excluded by the multivariate Cox model in node-negative patients, where only tumor size and estrogen receptor status retained a significant P-value. These results show that in breast carcinoma the cell growth fraction and the cell proliferation rate have a different prognostic impact with respect to the lymph node status and are major determinants of clinical outcome in node-positive patients only. Within this subgroup, the rapidity of cell proliferation as assessed by AgNOR analysis also served as a sensitive predictor of the response to adjuvant treatments.
14
314
323
Cell proliferation in breast cancer is a major determinant of clinical outcome in node-positive but not in node-negative patients / Trere, D; Ceccarelli, C; Migaldi, Mario; Santini, D; Taffurelli, M; Tosti, E; Chieco, P; Derenzini, M.. - In: APPLIED IMMUNOHISTOCHEMISTRY AND MOLECULAR MORPHOLOGY. - ISSN 1541-2016. - STAMPA. - 14:(2006), pp. 314-323.
Trere, D; Ceccarelli, C; Migaldi, Mario; Santini, D; Taffurelli, M; Tosti, E; Chieco, P; Derenzini, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/23046
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