Background and objectives: Human herpesvirus-6 (HHV-6) is the causative agent of exanthem subitum. Both HHV-6 variants, A and B, have been associated with central nervous system (CNS) diseases, suggesting a wide neuropathogenic potential. We describe a case of recurrent bilateral anterior optic neuritis with HHV-6 active infection associated with clinical relapses. Case report: A 23-year old woman presented with progressive visual impairment, bilateral papillitis and painful ocular movements. Nested polymerase chain reaction (PCR) for DNA viruses, HHV-6 variant specific real time quantitative PCR, serological analysis and retrotranscription PCR (RT-PCR) for HHV-6 mRNA transcripts were performed. Nested PCR in PBMC and CSF samples was negative for all viruses but positive for HHV-6 DNA, subtyped as HHV-6B. The disease had a relapsing/remitting course. During relapses PBMC samples remained positive for HHV-6 DNA, and HHV-6 active infection was confirmed by the presence of anti-HHV-6 IgM and of HHV-6 U27 mRNA transcript. High viremia levels and relapses were overlapping. After the last relapse, the patient was successfully treated with gancyclovir. Conclusions: The case reported here suggests a possible association of HHV-6 in bilateral optic neuritis. HHV-6 could be monitored when bilateral optic neuritis is identified, in order to establish an appropriate antiviral therapy. (c) 2006 Elsevier B.V. All rights reserved.
|Anno di pubblicazione:||2006|
|Titolo:||Human herpesvirus-6B active infection associated with relapsing bilateral anterior optic neuritis|
|Autore/i:||Moschettini D; Franceschini R; Vaccaro NM; Cermelli C; Pezzini F; Balestrieri M; Cerase A; Bartalini S; Ulivelli M; Tosi GM; Donati D|
|Codice identificativo ISI:||WOS:000242694700003|
|Codice identificativo Scopus:||2-s2.0-33751028510|
|Citazione:||Human herpesvirus-6B active infection associated with relapsing bilateral anterior optic neuritis / Moschettini D; Franceschini R; Vaccaro NM; Cermelli C; Pezzini F; Balestrieri M; Cerase A; Bartalini S; Ulivelli M; Tosi GM; Donati D. - In: JOURNAL OF CLINICAL VIROLOGY. - ISSN 1386-6532. - STAMPA. - 37(2006), pp. 244-247.|
|Tipologia||Articolo su rivista|
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